Gene: SPTBN4
Official Full Name: spectrin beta, non-erythrocytic 4provided by HGNC
Gene Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13750 | SPTBN4 Knockout cell line (HCT 116) | Human | SPTBN4 | 1:2~1:4 | Negative | Online Inquiry |
KO13751 | SPTBN4 Knockout cell line (HEK293) | Human | SPTBN4 | 1:3~1:6 | Negative | Online Inquiry |
KO13752 | SPTBN4 Knockout cell line (A549) | Human | SPTBN4 | 1:3~1:4 | Negative | Online Inquiry |
SPTBN4 Gene Knockout Cell Lines are specialized cellular models wherein the spectrin beta chain, non-erythrocytic 4 (SPTBN4) gene has been functionally disrupted. This process enables researchers to study the physiological and pathophysiological roles of SPTBN4 in a controlled environment. The knockout of the gene effectively eliminates its expression, allowing scientists to investigate the downstream effects on cellular processes such as cytoskeletal integrity, cell signaling pathways, and overall cellular behavior.
The primary mechanism through which these cell lines function is via the loss of SPTBN4 protein, a critical component of the cytoskeleton that plays a vital role in maintaining cell shape and mechanical stability. This disruption can lead to alterations in cellular adhesion, migration, and signal transduction, providing valuable insights into a range of biological processes and disease models. Crucially, these cell lines facilitate the exploration of conditions such as neurodegenerative diseases and cancers, where spectrin-related pathways are implicated.
In research and clinical settings, SPTBN4 Gene Knockout Cell Lines are instrumental in elucidating the molecular mechanisms underlying various diseases, thereby laying the groundwork for potential therapeutic interventions. By enabling direct experimentation on the effects of SPTBN4 absence, these models stand out for their ability to yield data that are directly translatable to human physiology, making them highly relevant for both academic and pharmaceutical research.
The distinct advantages of using SPTBN4 Gene Knockout Cell Lines over traditional cell lines include their specificity and reproducibility. Unlike alternatives that may still express low levels of the target gene, these knockout lines provide clearer insights into the biological roles of SPTBN4, thereby improving the quality of experimental outcomes.
Researchers and clinicians looking to deepen their understanding of cytoskeletal dynamics and their implications in health and disease will find substantial value in these cell lines. By utilizing SPTBN4 Gene Knockout Cell Lines, scientists can reveal new avenues for research and therapeutic strategies.
Our company brings decades of experience in producing high-quality biological products, ensuring that each of our offerings, including SPTBN4 Gene Knockout Cell Lines, meets the rigorous standards necessary for cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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