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SPTB Knockout Cell Lines

Gene: SPTB

Official Full Name: spectrin beta, erythrocyticprovided by HGNC

Gene Summary: This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13757 SPTB Knockout cell line (HCT 116) Human SPTB 1:2~1:4 Negative Online Inquiry
KO13758 SPTB Knockout cell line (HEK293) Human SPTB 1:3~1:6 Negative Online Inquiry

Background

SPTB Gene Knockout Cell Lines are specially engineered cellular models designed to study the functional role of the spectrin beta (SPTB) gene in various biological processes. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, which allows for precise genomic editing to disrupt the SPTB gene, thus enabling researchers to explore the consequences of its absence on cellular function, viability, and signaling pathways.

The key functions of SPTB in cellular contexts include maintaining cytoskeletal integrity, regulating cell shape, and facilitating cellular signaling pathways. By utilizing SPTB Gene Knockout Cell Lines, scientists can investigate how the loss of spectrin beta affects cellular dynamics and interactions, with implications for understanding various diseases linked to cytoskeletal defects, such as hereditary elliptocytosis and certain neurodegenerative disorders.

The scientific importance of these knockout cell lines extends to both research and clinical applications. In research settings, they serve as invaluable tools for elucidating the molecular mechanisms underlying spectrin-related disorders, while in clinical environments, they can assist in developing targeted therapies through a better understanding of disease pathology. Additionally, these models provide insights into how therapeutics may differentially affect cells with altered cytoskeletal components.

The advantages of the SPTB Gene Knockout Cell Lines in comparison to traditional models lie in their specificity and relevance. Whereas conventional models may only offer indirect insights into gene function, these knockout lines provide a clear-cut view of the consequences of gene disruption. This specificity allows researchers to generate reproducible data with high confidence levels, streamlining the research process significantly.

For researchers and clinicians alike, SPTB Gene Knockout Cell Lines are indispensable resources for advancing scientific knowledge and therapeutic development. Their utility in dissecting the roles of cytoskeletal proteins enhances research capabilities and promotes innovative strategies in the fight against related diseases.

With a commitment to quality and scientific rigor, our company specializes in providing state-of-the-art biological products that empower researchers and clinicians in their quests for breakthroughs in health and science. Our expertise in gene editing techniques enables us to deliver reliable and novel solutions, including the SPTB Gene Knockout Cell Lines, tailored to meet the complex needs of today’s scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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