Gene: SPIDR
Official Full Name: scaffold protein involved in DNA repairprovided by HGNC
Gene Summary: Involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Located in nuclear chromosome and nucleoplasm. Implicated in 46 XX gonadal dysgenesis. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29215 | SPIDR Knockout cell line (HeLa) | Human | SPIDR | 1:3~1:6 | Negative | Online Inquiry |
KO29216 | SPIDR Knockout cell line (HCT 116) | Human | SPIDR | 1:2~1:4 | Negative | Online Inquiry |
KO29217 | SPIDR Knockout cell line (HEK293) | Human | SPIDR | 1:3~1:6 | Negative | Online Inquiry |
KO29218 | SPIDR Knockout cell line (A549) | Human | SPIDR | 1:3~1:4 | Negative | Online Inquiry |
SPIDR Gene Knockout Cell Lines are sophisticated biological tools specifically engineered for the precise study of gene function and associated phenotypic consequences in mammalian cells. Utilizing the SPIDR (Split Marker-Insertion and Deletion of Reporter) system, these cell lines facilitate the targeted deletion of specific genes, thereby enabling researchers to dissect complex genetic pathways and investigate the role of particular genes in various biological processes. This technique is grounded in advanced CRISPR-Cas9 technology and offers an efficient and reliable means for gene editing.
The key mechanism at play in SPIDR Gene Knockout Cell Lines is the introduction of a dual-component system that allows for the seamless integration of a customizable knockout construct. This system requires fewer manipulations and significantly reduces off-target effects, ensuring that the resulting gene knockout is both accurate and reproducible. Researchers can effectively pinpoint the contributions of genes by analyzing changes in cellular function, which is invaluable for elucidating the molecular underpinnings of diseases.
The scientific importance of SPIDR Gene Knockout Cell Lines is underscored by their wide-ranging applications in fundamental research and translational science. These cell lines serve as essential models for studying cancer biology, neurodegenerative disorders, and regenerative medicine, among other fields. By allowing for the tailored investigation of gene function, they provide critical insights that could lead to the development of new therapeutic strategies or diagnostic tools.
Compared to traditional knockout methods, SPIDR technology stands out by minimizing the time and resources required for achieving gene disruptions and enhancing reliability through low-background noise. Users benefit from a more straightforward experimental workflow, enabling quicker hypothesis testing and validation.
For researchers and clinicians, the value of SPIDR Gene Knockout Cell Lines lies in their unparalleled specificity, efficiency, and accessibility in the age of personalized medicine. These tools empower investigations that can lead to transformative advancements in understanding gene function and therapeutic intervention.
Our company has extensive experience in the development of cutting-edge biological products, and we are committed to providing top-tier tools for researchers seeking to push the boundaries of genetic exploration. With SPIDR Gene Knockout Cell Lines, you can advance your research with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.