Home / SPATA18 Knockout Cell Lines

SPATA18 Knockout Cell Lines

Gene: SPATA18

Official Full Name: spermatogenesis associated 18provided by HGNC

Gene Summary: This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26515 SPATA18 Knockout cell line (HEK293) Human SPATA18 1:3~1:6 Negative Online Inquiry
KO26516 SPATA18 Knockout cell line (A549) Human SPATA18 1:3~1:4 Negative Online Inquiry

Background

SPATA18 Gene Knockout Cell Lines are engineered cellular models designed for the specific deletion of the SPATA18 gene, a critical element involved in spermatogenesis and fertility. These knockout cell lines enable researchers to investigate the physiological and pathological roles of SPATA18, providing insights into reproductive biology and associated disorders.

The key functions of SPATA18 are centered around its involvement in sperm development and maturation. By utilizing CRISPR-Cas9 technology, our SPATA18 knockout cell lines exhibit a precise deletion of the gene, thus allowing researchers to assess the consequences of SPATA18 loss on cellular pathways, gene expression patterns, and protein interactions. The ability to observe the downstream effects of this genetic alteration provides a powerful tool for elucidating the biological mechanisms of infertility and related conditions.

Scientifically, these knockout models have significant importance in both research and clinical settings. They can be used to explore the roles of SPATA18 in various aspects of spermatogenesis and its potential links to male fertility disorders. Moreover, they serve as invaluable platforms for drug testing and for the development of new therapeutic strategies for reproductive health.

Compared to alternative models, our SPATA18 gene knockout cell lines offer unmatched specificity, reliability, and reproducibility. Unlike traditional methods, which may include gene overexpression or RNA interference, our knockout technology delivers a precise and complete loss of function, making it an ideal choice for rigorous scientific investigations.

For researchers, clinicians, and biotechnological applications, the SPATA18 Gene Knockout Cell Lines represent a high-value asset. They facilitate deeper understanding of male reproductive biology and pave the way for advancements in infertility treatments and male contraceptive developments.

With years of expertise in genetic engineering and a commitment to enhancing research capabilities, our company is proud to provide high-quality biological products like the SPATA18 Gene Knockout Cell Lines. We continue to lead the way in developing innovative solutions that empower scientific discovery and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.