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SPAG16 Knockout Cell Lines

Gene: SPAG16

Official Full Name: sperm associated antigen 16provided by HGNC

Gene Summary: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13828 SPAG16 Knockout cell line (HeLa) Human SPAG16 1:3~1:6 Negative Online Inquiry
KO13829 SPAG16 Knockout cell line (HEK293) Human SPAG16 1:3~1:6 Negative Online Inquiry
KO13830 SPAG16 Knockout cell line (A549) Human SPAG16 1:3~1:4 Negative Online Inquiry

Background

SPAG16 Gene Knockout Cell Lines are advanced cellular models developed to facilitate the study of the SPAG16 gene, which is implicated in various biological processes including sperm motility and reproductive function. These cell lines are generated through precise gene editing technologies, such as CRISPR-Cas9, to create specific knockouts, enabling researchers to investigate the functional consequences of SPAG16 loss in controlled environments.

The primary function of the SPAG16 Gene Knockout Cell Lines is to provide a robust platform for investigating the gene's role in cellular signaling pathways, motility mechanisms, and overall cellular homeostasis. By removing SPAG16, researchers can assess changes in protein expression patterns, gene regulation, and other molecular roles that contribute to reproductive biology and potential infertility issues, making these models invaluable for both academic research and clinical applications.

From a scientific perspective, these knockout cell lines serve as essential tools in the exploration of genetic and molecular mechanisms underlying male fertility. They can be utilized in drug discovery, development of fertility treatments, and understanding genetic disorders linked to sperm function. Their reproducibility and high fidelity make them ideal for translational research aimed at developing targeted interventions.

What distinguishes SPAG16 Gene Knockout Cell Lines from alternative models is their specificity and reliability. Traditional models may not adequately capture the functional nuances of SPAG16, whereas our cell lines allow for meticulous examination of gene dysfunction in a controlled setting. Additionally, our product comes with comprehensive user protocols and scientific support, ensuring that researchers can promptly implement these tools in their studies.

For researchers and clinicians focusing on reproductive health and cellular biology, SPAG16 Gene Knockout Cell Lines represent an indispensable resource that could lead to breakthroughs in understanding male infertility and fertility-related disorders. Our company specializes in providing the highest quality biological products, backed by years of expertise in genetic engineering, ensuring that customers receive not only top-tier products but also the guidance necessary to propel their research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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