Gene: SP2
Official Full Name: Sp2 transcription factorprovided by HGNC
Gene Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35288 | SP2 Knockout cell line (HeLa) | Human | SP2 | 1:3~1:6 | Negative | Online Inquiry |
KO35289 | SP2 Knockout cell line (HCT 116) | Human | SP2 | 1:2~1:4 | Negative | Online Inquiry |
KO35290 | SP2 Knockout cell line (HEK293) | Human | SP2 | 1:3~1:6 | Negative | Online Inquiry |
KO35291 | SP2 Knockout cell line (A549) | Human | SP2 | 1:3~1:4 | Negative | Online Inquiry |
SP2 Gene Knockout Cell Lines are specifically engineered cellular models that allow researchers to study the function of the SP2 gene by effectively eliminating its expression through targeted gene editing techniques, such as CRISPR-Cas9. These knockout cell lines provide a powerful platform for investigating gene function and elucidating the biological pathways in which the SP2 gene is involved.
The key mechanism by which SP2 Gene Knockout Cell Lines operate is through precise genomic modifications that disrupt the coding sequence of the target gene. This can lead to a complete loss of function of the gene product, enabling the assessment of phenotypic changes related to SP2 modulation. This is crucial for understanding the gene's role in various cellular processes, including differentiation, proliferation, and response to environmental stimuli.
In terms of scientific importance, these cell lines have broad applications in molecular biology, genetics, and therapeutic development. They can be used in exploratory studies to define the role of SP2 in disease models, particularly in cancer research or developmental biology. Furthermore, the ability to assess the impact of gene loss on cellular behavior opens avenues for identifying potential new therapeutic targets.
What sets our SP2 Gene Knockout Cell Lines apart from other cell lines is our commitment to authenticity and quality. Each line is validated through rigorous testing, ensuring the absence of SP2 expression and demonstrating consistent performance. Unlike off-the-shelf alternatives, our lines are optimized for high specificity and reproducibility in experiments, making them the preferred choice for discerning researchers.
The value of SP2 Gene Knockout Cell Lines lies not only in enhancing the understanding of gene function but also in enabling translational research that can lead to novel treatments. Our expertise in cellular engineering and commitment to advancing research products ensures that you receive reliable and innovative tools to support your scientific inquiries. Rely on our products to propel your research forward and contribute to the growing body of knowledge in genetics and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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