Gene: SP1
Official Full Name: Sp1 transcription factorprovided by HGNC
Gene Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00181 | SP1 Knockout cell line (HEK293) | Human | SP1 | 1:3~1:6 | Negative | Online Inquiry |
KO11458 | SP1 Knockout cell line (HeLa) | Human | SP1 | 1:3~1:6 | Negative | Online Inquiry |
KO11459 | SP1 Knockout cell line (HCT 116) | Human | SP1 | 1:2~1:4 | Negative | Online Inquiry |
KO11460 | SP1 Knockout cell line (A549) | Human | SP1 | 1:3~1:4 | Negative | Online Inquiry |
SP1 Gene Knockout Cell Lines are advanced biological tools engineered to lack the expression of the SP1 transcription factor, which plays a critical role in regulating gene expression across various cellular processes. SP1 is known for its involvement in cellular growth, differentiation, and apoptosis, making its knockout a key model for studying its underlying mechanisms and pathways in various biological contexts.
The primary function of SP1 Gene Knockout Cell Lines is to facilitate the exploration of gene regulatory networks and their impact on cellular behavior. By eliminating SP1 expression, researchers can assess the consequent effects on gene transcription, protein interactions, and phenotypic outcomes, providing invaluable insight into gene function and potential therapeutic targets. The specificity of this knockout technology ensures that the observed changes are directly attributable to the absence of SP1, thereby enhancing the reliability of experimental results.
These cell lines hold significant value in both research and clinical settings. They are integral to investigations in cancer biology, where SP1 is frequently dysregulated, contributing to tumor progression and metastasis. Furthermore, these models can aid in drug discovery efforts aimed at modulating pathways influenced by SP1, ultimately leading to more effective therapeutic strategies.
One of the notable advantages of SP1 Gene Knockout Cell Lines compared to alternative methods, such as transient gene silencing techniques, is their stability and reproducibility over time. Researchers can cultivate these cell lines to generate a consistent population of cells for long-term studies, reducing variability and enhancing the reliability of data derived from experiments.
For researchers, clinicians, and laboratory technicians seeking to deepen their understanding of gene regulation and its implications in health and disease, SP1 Gene Knockout Cell Lines represent a powerful asset. Their specificity and robustness enable transformative research that can pave the way for novel therapies and improved patient outcomes.
Our company stands at the forefront of biotechnological innovation, providing these cutting-edge SP1 Gene Knockout Cell Lines alongside superior customer support and expertise. We are committed to empowering the scientific community with high-quality products that drive advancements in biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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