Gene: SOX9
Official Full Name: SRY-box transcription factor 9provided by HGNC
Gene Summary: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00033 | SOX9 Knockout cell line (AGS) | Human | SOX9 | 1:2~1:4 | Negative | Online Inquiry |
KO00552 | SOX9 Knockout cell line (A549) | Human | SOX9 | 1:3~1:4 | Negative | Online Inquiry |
KO09856 | SOX9 Knockout cell line (HeLa) | Human | SOX9 | 1:3~1:6 | Negative | Online Inquiry |
KO09857 | SOX9 Knockout cell line (HCT 116) | Human | SOX9 | 1:2~1:4 | Negative | Online Inquiry |
KO09858 | SOX9 Knockout cell line (HEK293) | Human | SOX9 | 1:3~1:6 | Negative | Online Inquiry |
SOX9 Gene Knockout Cell Lines are specialized biological products designed to facilitate the in-depth study of the SOX9 transcription factor, a pivotal regulator in various developmental processes, including chondrogenesis and sexually dimorphic gene expression. These cell lines have been engineered using CRISPR-Cas9 technology to effectively disable the SOX9 gene, thus enabling researchers to investigate the functional roles and pathway interactions of SOX9 in a controlled environment.
The key function of these knockout cell lines lies in their ability to serve as a powerful tool for dissecting molecular mechanisms behind SOX9-related pathologies, including skeletal disorders and certain cancers. By eliminating the SOX9 gene, researchers can observe the resultant phenotypic changes, allowing for the establishment of causative links between gene regulation and cellular behavior. This mechanistic insight is invaluable for understanding complex biological systems and developing targeted therapies.
Scientifically, SOX9 Gene Knockout Cell Lines are particularly important in both research and clinical settings. They provide a platform for drug screening, gene therapy development, and the study of disease models that rely on the dysregulation of SOX9. Furthermore, they are crucial in understanding tissue differentiation and regeneration, essential areas of focus in regenerative medicine.
Compared to conventional methods of gene manipulation, such as RNA interference or traditional gene editing techniques, SOX9 Gene Knockout Cell Lines offer several advantages. The CRISPR-Cas9 approach ensures precise and efficient gene disruption, leading to stable cell lines that exhibit consistent behavior across multiple experiments. This reliability reduces variability and enhances the reproducibility of research findings.
For researchers and clinicians alike, the value of SOX9 Gene Knockout Cell Lines is clear. They are essential for advancing our knowledge of fundamental biological processes and for devising innovative therapeutic strategies. With their wide applicability in both basic and applied sciences, these cell lines are a critical addition to any laboratory focused on genetic research or translational medicine.
Our company specializes in the development of high-quality biological products geared towards accelerating scientific discovery. With cutting-edge technologies and a commitment to excellence, we ensure that our offerings meet the highest standards of precision and reliability for research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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