Gene: SOCS6
Official Full Name: suppressor of cytokine signaling 6provided by HGNC
Gene Summary: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11170 | SOCS6 Knockout cell line (HeLa) | Human | SOCS6 | 1:3~1:6 | Negative | Online Inquiry |
KO11171 | SOCS6 Knockout cell line (HCT 116) | Human | SOCS6 | 1:2~1:4 | Negative | Online Inquiry |
KO11172 | SOCS6 Knockout cell line (HEK293) | Human | SOCS6 | 1:3~1:6 | Negative | Online Inquiry |
KO11173 | SOCS6 Knockout cell line (A549) | Human | SOCS6 | 1:3~1:4 | Negative | Online Inquiry |
SOCS6 Gene Knockout Cell Lines represent a sophisticated biological tool designed for the in-depth study of the Suppressor of Cytokine Signaling 6 (SOCS6) gene, which plays a crucial role in cellular signaling pathways, particularly in immune response and metabolism regulation. These cell lines have been genetically engineered to lack functional SOCS6, thereby enabling researchers to investigate the gene’s contributions to various physiological processes, including cytokine signaling, cell growth, and differentiation.
The primary function of SOCS6 involves the negative regulation of cytokine signaling pathways, akin to other members of the SOCS family. By employing these knockout cell lines, scientists can explore the mechanistic impacts of SOCS6 deficiency, revealing alterations in signaling cascades and subsequent cellular phenotype changes. Moreover, SOCS6 has implications in oncogenesis and metabolic disorders, making these knockout models invaluable in understanding tumor biology and metabolic disease mechanisms.
Scientifically, SOCS6 Gene Knockout Cell Lines are instrumental for large-scale screening applications, proteomic studies, and functional assays within both research and clinical settings. They facilitate the assessment of drug efficacy against SOCS6-related pathways, offering a clear avenue for therapeutic development aimed at managing disorders linked to dysregulated cytokine signaling.
Compared to competing products, these knockout cell lines offer rigorous validation of SOCS6 deletion and consistent performance across various experimental conditions. Furthermore, they are derived from well-characterized parental cell lines, ensuring a more reliable background for experimental reproducibility.
For researchers and clinicians seeking to expand their understanding of SOCS6's role in cellular processes or develop targeted therapies, the SOCS6 Gene Knockout Cell Lines represent an essential resource. These lines not only enhance experimental outcomes but also contribute significantly to the advancement of personalized medicine strategies.
At our company, we are committed to delivering high-quality biological products and services to facilitate cutting-edge research. Our expertise in gene editing and cell line development ensures that our offerings meet the stringent needs of today’s scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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