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SOCS3 Knockout Cell Lines

Gene: SOCS3

Official Full Name: suppressor of cytokine signaling 3provided by HGNC

Gene Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00371 SOCS3 gRNA3-gRNA4 KO plasmid SOCS3 $850
KO00652 SOCS3 Knockout cell line(BEAS-2B) Human SOCS3 1:3~1:4 Negative Online Inquiry
KO01331 SOCS3 Knockout cell line (HeLa) Human SOCS3 1:3~1:6 Negative Online Inquiry
KO11182 SOCS3 Knockout cell line (HCT 116) Human SOCS3 1:2~1:4 Negative Online Inquiry
KO11183 SOCS3 Knockout cell line (HEK293) Human SOCS3 1:3~1:6 Negative Online Inquiry
KO11184 SOCS3 Knockout cell line (A549) Human SOCS3 1:3~1:4 Negative Online Inquiry

Background

SOCS3 Gene Knockout Cell Lines are specialized cell lines in which the Suppressor of Cytokine Signaling 3 (SOCS3) gene has been specifically ablated to facilitate the study of its biological roles in cellular signaling pathways, particularly those involving cytokine-mediated effects. SOCS3 is a critical regulator that modulates the signaling pathways of various cytokines, including those in the interleukin and interferon families, making these knockout cell lines invaluable for exploring the functional aspects of SOCS3 in both normal and pathological states.

The key mechanism of action in these cell lines involves the disruption of the SOCS3 protein, resulting in enhanced signaling through its target pathways. Researchers can investigate the consequences of SOCS3 deficiency, leading to an improved understanding of inflammatory responses, immune regulation, and the pathology of various diseases, including cancer and autoimmune disorders. The ability to manipulate SOCS3 provides insight into its potential therapeutic targets, allowing for the exploration of innovative treatment strategies.

In scientific research and clinical applications, these SOCS3 Gene Knockout Cell Lines hold significant value by enabling researchers to delineate the downstream effects of SOCS3 signaling disruption. They are particularly useful for elucidating the mechanisms by which immune cells respond to stimuli and how these pathways contribute to disease processes, thus enhancing our understanding of functional immunology.

A notable advantage of our SOCS3 knockout cell lines is their robust validation and consistent performance across various experimental setups. Compared to traditional methods such as transient siRNA knockdown, our stable cell lines provide a more reliable and reproducible system for long-term studies, leading to higher confidence in experimental outcomes. Additionally, these cell lines are available in various backgrounds, allowing for tailored experiments based on specific research needs.

For researchers and clinicians aiming to investigate the complexities of cytokine signaling and immune regulation, our SOCS3 Gene Knockout Cell Lines represent an essential resource that can accelerate discoveries and ultimately lead to improved therapeutic interventions. Our company prides itself on excellence in providing cutting-edge biological tools backed by extensive research expertise, ensuring that our customers have access to the highest quality products for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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