Gene: SNX6
Official Full Name: sorting nexin 6provided by HGNC
Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13866 | SNX6 Knockout cell line (HeLa) | Human | SNX6 | 1:3~1:6 | Negative | Online Inquiry |
KO13867 | SNX6 Knockout cell line (HCT 116) | Human | SNX6 | 1:2~1:4 | Negative | Online Inquiry |
KO13868 | SNX6 Knockout cell line (HEK293) | Human | SNX6 | 1:3~1:6 | Negative | Online Inquiry |
KO13869 | SNX6 Knockout cell line (A549) | Human | SNX6 | 1:3~1:4 | Negative | Online Inquiry |
SNX6 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate in-depth research into the role of the Sorting Nexin 6 gene (SNX6) in various biological processes. These cell lines have undergone precise genetic modification to create a complete knockout of the SNX6 gene, allowing researchers to investigate the physiological and pathological impacts of its absence on cellular functions. By leveraging CRISPR/Cas9 technology or similar genome editing approaches, these knockout cell lines serve as a vital tool for dissecting the complex signaling pathways in which SNX6 is involved, such as endocytosis, vesicle trafficking, and cellular responses to stimuli.
The primary function of SNX6 involves regulation of the endosomal system, which plays a crucial role in cell signaling and nutrient uptake. By studying these gene knockout cell lines, researchers can gain insights into disease mechanisms, particularly in contexts such as cancer biology, neurodegeneration, and metabolic disorders, where SNX6 activity may be dysregulated. The ability to generate data from these specialized models enhances understanding of disease states and informs potential therapeutic strategies, making them invaluable in both basic and translational research settings.
Compared to alternative models, such as wild-type or overexpression systems, the SNX6 Gene Knockout Cell Lines provide a unique advantage by offering a clean background to examine loss-of-function effects without confounding variables. This specificity enables more accurate correlation of SNX6 deficiency with observed phenotypic changes, aiding in the identification of potential targets for drug development and therapeutic interventions.
With our extensive expertise in genomic technologies and a focus on providing high-quality biological products, our company is committed to empowering researchers and clinicians with tools that enhance their investigative capabilities. Our SNX6 Gene Knockout Cell Lines are more than just research tools; they represent a step forward in understanding complex biological mechanisms and developing innovative applications that can ultimately lead to improved health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.