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SNX17 Knockout Cell Lines

Gene: SNX17

Official Full Name: sorting nexin 17provided by HGNC

Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05355 SNX17 Knockout cell line (HeLa) Human SNX17 1:3~1:6 Negative Online Inquiry
KO05356 SNX17 Knockout cell line (HCT 116) Human SNX17 1:2~1:4 Negative Online Inquiry
KO05357 SNX17 Knockout cell line (HEK293) Human SNX17 1:3~1:6 Negative Online Inquiry
KO05358 SNX17 Knockout cell line (A549) Human SNX17 1:3~1:4 Negative Online Inquiry

Background

SNX17 Gene Knockout Cell Lines are specialized cellular assays engineered to lack the expression of the SNX17 gene, which encodes for sorting nexin 17, a protein involved in endosomal trafficking and cellular signaling pathways. These cell lines serve as critical tools in elucidating the role of SNX17 in various biological processes, including receptor recycling, cargo sorting, and cellular response to extracellular stimuli. By employing CRISPR-Cas9 gene editing technology, these knockout models enable researchers to assess the functional consequences of SNX17 absence at both cellular and molecular levels.

The primary function of SNX17 involves its participation in the endosomal recycling pathway, where it interacts with specific receptors and cargoes to promote their return to the plasma membrane. In the absence of SNX17, researchers can observe alterations in receptor availability, signaling efficacy, and cellular responses, making these cell lines essential for investigating the implications of disrupted endosomal sorting in diseases such as cancer and metabolic disorders.

The scientific importance of SNX17 Gene Knockout Cell Lines extends to both research and clinical applications. They provide a platform for studying the intricate mechanisms of receptor-mediated signaling and endocytic pathways, which are critical in understanding disease progression and drug response. Moreover, they offer potential preclinical models for therapeutic interventions targeting endosomal trafficking.

One of the standout advantages of our SNX17 Gene Knockout Cell Lines is their high specificity and reproducibility, compared to conventional methods that may yield off-target effects or inconsistent results. This precision allows researchers to confidently draw conclusions regarding the role of SNX17 in their experimental models.

Researchers, clinicians, and industry professionals will find significant value in these knockout cell lines as they facilitate groundbreaking discoveries in cellular biology and therapeutic development. The ability to understand and manipulate these pathways can lead to advancements in targeted therapies and innovative treatment strategies.

Our company is dedicated to providing high-quality biological products and expertise in gene editing technologies, ensuring that researchers have access to reliable tools that support their quest for discovery and innovation in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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