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SNRPB2 Knockout Cell Lines

Gene: SNRPB2

Official Full Name: small nuclear ribonucleoprotein polypeptide B2provided by HGNC

Gene Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13870 SNRPB2 Knockout cell line (HeLa) Human SNRPB2 1:3~1:6 Negative Online Inquiry
KO13871 SNRPB2 Knockout cell line (HCT 116) Human SNRPB2 1:2~1:4 Negative Online Inquiry
KO13872 SNRPB2 Knockout cell line (HEK293) Human SNRPB2 1:3~1:6 Negative Online Inquiry
KO13873 SNRPB2 Knockout cell line (A549) Human SNRPB2 1:3~1:4 Negative Online Inquiry

Background

SNRPB2 Gene Knockout Cell Lines are genetically engineered cellular models that lack the SNRPB2 gene, which encodes a critical component of the spliceosome involved in pre-mRNA splicing. These knockout cell lines serve as essential tools for investigating the functional role of SNRPB2 in cellular processes, particularly in gene expression regulation and RNA processing. By eliminating the SNRPB2 gene, researchers can observe and analyze alterations in cellular phenotypes, splicing efficiency, and downstream effects on various signaling pathways.

The key mechanism underlying the utility of SNRPB2 Gene Knockout Cell Lines lies in their ability to reproduce the effects of SNRPB2 deficiency, enabling the dissection of compensatory pathways and molecular networks that may alter in its absence. This ability to create precise gene disruptions facilitates robust comparisons with wild-type cell lines, empowering researchers to make novel discoveries concerning splicing-related disorders, cancer biology, and the overall impact of RNA metabolism.

Scientifically, the importance of these knockout cell lines extends to both research and clinical applications, particularly in studies aimed at unraveling the etiology of diseases linked to splicing defects, such as certain cancers and genetic syndromes. They present an invaluable resource for pharmacological studies involving drug development targeting splicing mechanisms and may also contribute to the understanding of personalized medicine approaches in treating spliceosome-related diseases.

SNRPB2 Gene Knockout Cell Lines offer distinct advantages, such as enhanced specificity in experimental designs compared to conventional cell lines where splicing dynamics are still active. This specificity leads to clearer insights and more reproducible results, ultimately benefiting the research community. Moreover, our product boasts a high level of customization and quality assurance, ensuring that researchers receive the most reliable and relevant genetic models.

In a rapidly evolving field where precision is paramount, SNRPB2 Gene Knockout Cell Lines embody our commitment to advancing scientific knowledge. With years of experience in biological products development and a dedicated team of experts, our company stands as a leader in delivering innovative and effective solutions tailored to the needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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