Gene: SNRPA
Official Full Name: small nuclear ribonucleoprotein polypeptide Aprovided by HGNC
Gene Summary: The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35334 | SNRPA Knockout cell line (HeLa) | Human | SNRPA | 1:3~1:6 | Negative | Online Inquiry |
KO35335 | SNRPA Knockout cell line (HCT 116) | Human | SNRPA | 1:2~1:4 | Negative | Online Inquiry |
KO35336 | SNRPA Knockout cell line (HEK293) | Human | SNRPA | 1:3~1:6 | Negative | Online Inquiry |
KO35337 | SNRPA Knockout cell line (A549) | Human | SNRPA | 1:3~1:4 | Negative | Online Inquiry |
SNRPA Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to investigate the role of the SNRPA gene in cellular processes, such as splicing and RNA metabolism. By utilizing CRISPR-Cas9 technology, these cell lines have been meticulously created to exhibit a complete loss of SNRPA function, enabling researchers to elucidate mechanistic pathways that are often obscured in wild-type cells.
The primary function of SNRPA is to participate in the assembly of the spliceosome, a critical complex involved in pre-mRNA splicing. The SNRPA gene encodes a protein that is essential for the recognition and processing of introns and exons, thereby influencing gene expression and regulatory mechanisms. Using these knockout cell lines, scientists can perform in-depth analyses of splicing dynamics, explore the consequences of aberrant RNA processing, and assess the cellular response to various stressors or pharmacological agents, offering insights into diseases such as cancer and genetic disorders.
In terms of scientific importance, SNRPA Gene Knockout Cell Lines serve as invaluable tools for basic and applied research, particularly in the fields of molecular biology, genomics, and pharmacology. Their ability to shed light on essential biological mechanisms positions them as crucial resources for researchers aiming to develop novel therapeutic strategies.
One of the unique selling points of these cell lines is their specificity and reliability when compared to alternative models, such as traditional siRNA or chemical inhibition methods. With stable and heritable gene knockout, these models provide consistent results, minimizing variability and allowing for reproducible experimental outcomes. This reliability enhances data integrity, making the SNRPA cell lines an attractive choice for both academic and clinical laboratories.
Investing in SNRPA Gene Knockout Cell Lines can profoundly accelerate the pace of discovery in research and therapeutic development, empowering scientists and clinicians to push the boundaries of knowledge. Our company prides itself on its robust expertise in genetic engineering and cell line development, ensuring that we deliver high-quality, well-characterized models that meet the stringent demands of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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