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SMPDL3B Knockout Cell Lines

Gene: SMPDL3B

Official Full Name: sphingomyelin phosphodiesterase acid like 3Bprovided by HGNC

Gene Summary: Enables phosphoric diester hydrolase activity. Predicted to be involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27679 SMPDL3B Knockout cell line (HCT 116) Human SMPDL3B 1:2~1:4 Negative Online Inquiry
KO27680 SMPDL3B Knockout cell line (HEK293) Human SMPDL3B 1:3~1:6 Negative Online Inquiry
KO27681 SMPDL3B Knockout cell line (A549) Human SMPDL3B 1:3~1:4 Negative Online Inquiry

Background

SMPDL3B Gene Knockout Cell Lines are genetically modified cell lines that have had the SMPDL3B gene precisely disrupted through advanced gene-editing techniques such as CRISPR-Cas9. This novel product allows researchers to study the gene's function and elucidate its role in various biological processes, particularly in relation to cellular signaling and immune responses. The knockout of the SMPDL3B gene can lead to significant alterations in phosphatidylinositol signaling pathways, affecting the metabolism of lipids and potentially influencing disease states such as cancer and autoimmune disorders.

These cell lines provide a robust platform for functional assays, enabling the investigation of SMPDL3B's mechanism of action in both normal physiological conditions and pathological contexts. In research applications, these knockout models are invaluable for understanding gene function and for drug discovery efforts that aim to target specific pathways associated with SMPDL3B. Their utility also extends to preclinical studies, where they help in identifying biomarkers for therapy responsiveness and disease progression.

One of the primary advantages of using SMPDL3B Gene Knockout Cell Lines over other alternatives is their precise genetic modification, which allows for unambiguous interpretations of results. Unlike other methods that may induce off-target effects, these knockout models ensure high specificity in research outcomes. Furthermore, our cell lines are rigorously validated for consistent performance, giving researchers the confidence needed for reproducible results.

For researchers and clinicians, the value of SMPDL3B Gene Knockout Cell Lines lies in their capacity to accelerate discoveries in the fields of cell biology, immunology, and oncology. Detailed investigation into the SMPDL3B gene can illuminate cancer mechanisms and foster the development of novel therapeutic strategies aimed at treating diseases closely associated with this signaling pathway.

By choosing our SMPDL3B Gene Knockout Cell Lines, users can leverage our extensive expertise in genetic engineering and molecular biology. Our commitment to providing high-quality products ensures that researchers have access to the best tools available to push the frontiers of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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