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SLC6A17 Knockout Cell Lines

Gene: SLC6A17

Official Full Name: solute carrier family 6 member 17provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the SLC6 family of transporters, which are responsible for the presynaptic uptake of most neurotransmitters. The encoded vesicular transporter is selective for proline, glycine, leucine and alanine. In mouse, the strongest expression of this gene was in cortical and hippocampal tissues where expression increased during embryonic brain development and peaked postnatally. Defects in this gene cause a form of autosomal recessive intellectual disability. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14103 SLC6A17 Knockout cell line (HCT 116) Human SLC6A17 1:2~1:4 Negative Online Inquiry
KO14104 SLC6A17 Knockout cell line (A549) Human SLC6A17 1:3~1:4 Negative Online Inquiry

Background

SLC6A17 Gene Knockout Cell Lines are genetically engineered cellular models that have had the SLC6A17 gene inactivated. This gene encodes a member of the solute carrier family 6, which is involved in the transport of various neurotransmitters and small molecules, playing a critical role in neuronal function and signaling. By knocking out this specific gene, researchers can study the resultant phenotypic changes, elucidating the complexities of neurotransmitter dynamics and their implications in neurobiological processes.

The key function of these cell lines is to facilitate detailed investigations into the mechanisms and pathways affected by the loss of SLC6A17. Using CRISPR-Cas9 technology for precise gene editing, these knockout models allow for the observation of alterations in neurotransmitter uptake and release, cell signaling cascades, and subsequent physiological responses. Importantly, this allows researchers to explore the gene's involvement in various neurological disorders and conditions, providing insights that may lead to the development of targeted therapeutics.

The scientific importance of SLC6A17 Gene Knockout Cell Lines extends to both research and clinical applications, bridging the gap between basic science and translational medicine. These models serve as invaluable tools for pharmacological testing, enabling the evaluation of drug effects on neurotransmitter transport processes in a controlled environment, thereby paving the way for innovative therapeutic strategies in disorders such as depression and schizophrenia.

The advantages of utilizing SLC6A17 Gene Knockout Cell Lines are manifold. Unlike traditional methods, these knockout models offer high specificity and reproducibility, reducing off-target effects and allowing for clear interpretation of results. This specificity enhances data quality, which is critical for researchers striving to publish significant findings in competitive fields.

For researchers and clinicians alike, the value of SLC6A17 Gene Knockout Cell Lines lies in their capacity to generate robust, reliable data that can guide both fundamental research and therapeutic development. By using these advanced cellular models, scientists can gain unprecedented insights into gene function, contributing to a deeper understanding of neurobiology.

Our company specializes in providing high-quality genetic models and tools tailored for the research community, leveraging cutting-edge technologies to support the scientific endeavors of our customers. With a commitment to innovation, we ensure that our product offerings meet the demands of modern biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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