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SLC39A6 Knockout Cell Lines

Gene: SLC39A6

Official Full Name: solute carrier family 39 member 6provided by HGNC

Gene Summary: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09962 SLC39A6 Knockout cell line (HeLa) Human SLC39A6 1:3~1:6 Negative Online Inquiry
KO09963 SLC39A6 Knockout cell line (HCT 116) Human SLC39A6 1:2~1:4 Negative Online Inquiry
KO09964 SLC39A6 Knockout cell line (HEK293) Human SLC39A6 1:3~1:6 Negative Online Inquiry
KO09965 SLC39A6 Knockout cell line (A549) Human SLC39A6 1:3~1:4 Negative Online Inquiry

Background

SLC39A6 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the SLC39A6 gene. This gene encodes a member of the solute carrier family, which is involved in the transport of metal ions across cellular membranes. By knocking out SLC39A6, researchers can investigate the role of this transporter in various physiological processes, including metal ion homeostasis, cellular signaling, and potential implications in disease states such as neurological disorders and cancer.

The primary function of these knockout cell lines is to provide a model system for studying the effects of SLC39A6 deficiency on cellular behavior. By comparing the knockout cell lines to their wild-type counterparts, researchers can delineate the specific contributions of the SLC39A6 gene in regulating cellular functions, such as proliferation, differentiation, and response to metal ion substrates. The mechanistic insights gained can be invaluable for understanding the intricate biology of metal ion transport and its broader contextual relevance in health and disease.

In terms of scientific importance, SLC39A6 Gene Knockout Cell Lines serve as essential tools in both basic and applied research. They allow for high-throughput screening of potential therapeutic compounds that may target metal ion transport pathways. Furthermore, these cell lines are particularly relevant in studying conditions where metal ion dysregulation occurs, such as heavy metal toxicity and associated pathologies.

When compared to other models, the SLC39A6 Gene Knockout Cell Lines offer distinct advantages, including the ability to study specific genetic alterations at the cellular level without the confounding factors present in whole organism models. This specificity allows for more controlled experimental conditions and reproducible results, making them highly attractive to researchers focused on the molecular mechanisms of disease.

For researchers and clinicians, the value of these cell lines lies in their ability to facilitate insights into the nuanced roles of metal transporters, ultimately guiding therapeutic strategies and enhancing our understanding of disease mechanisms. As an established leader in the development of advanced biological products, our company is committed to providing high-quality knockout cell lines, ensuring that scientists have the best resources for pioneering research.

Please note that all services are for research use only. Not intended for any clinical use.

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