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SLC37A2 Knockout Cell Lines

Gene: SLC37A2

Official Full Name: solute carrier family 37 member 2provided by HGNC

Gene Summary: Enables glucose 6-phosphate:phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28365 SLC37A2 Knockout cell line (HCT 116) Human SLC37A2 1:2~1:4 Negative Online Inquiry

Background

SLC37A2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the SLC37A2 gene, which encodes for a transport protein involved in the glucose-6-phosphate transport system. These cell lines serve as invaluable tools for researchers investigating metabolic processes, disease mechanisms, and biochemical pathways influenced by glucose homeostasis. The knockout of SLC37A2 enables a clear examination of the gene's function and its impact on cellular processes, offering insights into energy metabolism and signaling pathways.

The core mechanism by which these knockout cell lines operate involves the complete ablation of SLC37A2, leading to alterations in glucose metabolism. This induced deficiency can result in heightened understanding of pathophysiological conditions, such as diabetes or metabolic syndrome, where glucose transport is impaired. Researchers can utilize these models to assess the consequences of SLC37A2 loss on cellular activities like proliferation, differentiation, and response to various stimuli, thus contributing to our knowledge of metabolic diseases.

The scientific importance of SLC37A2 Knockout Cell Lines extends to both fundamental research and clinical applications. They provide a platform for testing the efficacy of new therapeutic interventions targeting SLC37A2-related pathways or for screening potential drugs that could modulate glucose transport mechanisms. Furthermore, these cell lines can be instrumental in elucidating the role of SLC37A2 in various cancers, where altered glucose metabolism is a hallmark.

Compared to alternative models, SLC37A2 Knockout Cell Lines offer several unique advantages. Their specificity for the SLC37A2 gene provides clarity and eliminates confounding factors that may arise from using less targeted approaches such as chemical inhibitors or RNA interference. Additionally, they provide reproducibility and consistency, essential for validating experimental outcomes across diverse research laboratories.

For researchers and clinicians focused on understanding metabolic disorders or developing innovative therapeutic strategies, SLC37A2 Gene Knockout Cell Lines represent a crucial resource. The ability to examine the precise role of this gene in controlled cellular environments aids in accelerating the discovery of new treatments.

Our company is dedicated to advancing biomedical research by providing high-quality, expertly curated cell lines and biological products that empower scientists to achieve breakthroughs in their studies. With a commitment to innovation and excellence, we enable researchers to navigate the complexities of biological systems with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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