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SLC30A5 Knockout Cell Lines

Gene: SLC30A5

Official Full Name: solute carrier family 30 member 5provided by HGNC

Gene Summary: This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14041 SLC30A5 Knockout cell line (HeLa) Human SLC30A5 1:3~1:6 Negative Online Inquiry
KO14042 SLC30A5 Knockout cell line (HCT 116) Human SLC30A5 1:2~1:4 Negative Online Inquiry
KO14043 SLC30A5 Knockout cell line (HEK293) Human SLC30A5 1:3~1:6 Negative Online Inquiry
KO14044 SLC30A5 Knockout cell line (A549) Human SLC30A5 1:3~1:4 Negative Online Inquiry

Background

SLC30A5 Gene Knockout Cell Lines are specifically engineered cellular models in which the SLC30A5 gene has been inactivated, creating a robust tool for investigating the role of this gene in various physiological and pathological processes. The SLC30A5 gene encodes a zinc transporter, critical for maintaining zinc homeostasis within cells, and its disruption can help elucidate the gene's function, particularly in relation to cellular signaling, metal ion transport, and tissue-specific roles in human health and disease.

The primary mechanism by which SLC30A5 Gene Knockout Cell Lines operate involves gene editing techniques, such as CRISPR/Cas9, to create a loss-of-function variant that allows researchers to observe the resultant phenotypic changes compared to wild-type counterparts. This model system serves as a pivotal assistant in deciphering the molecular pathways influenced by zinc deficiency or overload, thereby enabling researchers to explore the implications in conditions such as neurodegenerative diseases, cancer, and metabolic syndromes.

Scientifically, these cell lines are invaluable in both research and clinical settings. They provide an essential platform for drug screening, gene therapy exploration, and understanding disease mechanisms associated with zinc dysregulation. Their potential applications extend into personalized medicine, where understanding individual genetic variations can lead to tailored therapeutic strategies.

What sets SLC30A5 Gene Knockout Cell Lines apart from conventional cell models is their unparalleled specificity and accuracy in mimicking pathological states related to zinc metabolism. Unlike non-targeted cell lines, these knockout variants enable precise manipulation of the SLC30A5 gene, providing clarity in experimental outcomes and reducing off-target effects throughout downstream analyses.

For researchers and clinicians focused on elucidating the complexities of zinc transport and its implications for health, the SLC30A5 Gene Knockout Cell Lines represent a cutting-edge resource. They offer both reliability and reproducibility, essential characteristics for advancing scientific knowledge and developing novel therapeutic approaches. Our company specializes in producing high-quality genetic models that empower scientists, and we are committed to supporting innovative research that addresses critical health challenges.

Please note that all services are for research use only. Not intended for any clinical use.

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