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SLC29A4 Knockout Cell Lines

Gene: SLC29A4

Official Full Name: solute carrier family 29 member 4provided by HGNC

Gene Summary: This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26814 SLC29A4 Knockout cell line (HCT 116) Human SLC29A4 1:2~1:4 Negative Online Inquiry
KO26815 SLC29A4 Knockout cell line (HEK293) Human SLC29A4 1:3~1:6 Negative Online Inquiry
KO26816 SLC29A4 Knockout cell line (A549) Human SLC29A4 1:3~1:4 Negative Online Inquiry

Background

SLC29A4 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the SLC29A4 gene, which encodes the human concentrative nucleoside transporter 4 (CNT4). This gene plays a pivotal role in nucleoside uptake and is implicated in various physiological processes, including neurotransmission and cellular metabolism. The knockout of the SLC29A4 gene allows researchers to investigate its function and the associated biological pathways by observing the phenotypic changes that occur in its absence.

The key mechanism of these knockout cell lines is their ability to facilitate the study of nucleoside transport dynamics, which ultimately assists in elucidating the molecular mechanisms behind pathologies such as neurological disorders, cancer, and cardiovascular diseases. By utilizing CRISPR-Cas9 technology, our product ensures a highly efficient and specific disruption of the targeted gene, thus providing a robust model for downstream applications, including drug screening, gene function studies, and biomarker discovery.

The scientific significance of SLC29A4 Gene Knockout Cell Lines extends to both research and clinical settings. They enable researchers to explore therapeutic interventions aimed at modulating nucleoside transporter activity and understanding the implications on drug metabolism and efficacy, particularly for nucleoside analogs in cancer therapy. These cell lines serve as an invaluable resource for companies engaged in drug development, as they provide a reliable mechanism for identifying novel targets and treatments.

Compared to existing alternatives, our SLC29A4 Gene Knockout Cell Lines stand out due to their unparalleled specificity and reproducibility in gene disruption. This leads to more consistent experimental results and supports higher-quality data for publication or development purposes. Researchers and clinicians will find immense value in utilizing these cell lines, as they provide a profound understanding of the SLC29A4 gene’s role, ultimately aiding in the advancement of personalized medicine approaches.

Our commitment to excellence in genetic engineering, combined with years of expertise in providing high-quality biological products, positions us as a leading supplier of innovative knockout cell lines. With a focus on supporting groundbreaking research efforts, we empower scientists and healthcare professionals to unlock new insights in molecular biology and translational medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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