Gene: SLC27A2
Official Full Name: solute carrier family 27 member 2provided by HGNC
Gene Summary: The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31340 | SLC27A2 Knockout cell line (HeLa) | Human | SLC27A2 | 1:3~1:6 | Negative | Online Inquiry |
KO31341 | SLC27A2 Knockout cell line (HCT 116) | Human | SLC27A2 | 1:2~1:4 | Negative | Online Inquiry |
KO31342 | SLC27A2 Knockout cell line (HEK293) | Human | SLC27A2 | 1:3~1:6 | Negative | Online Inquiry |
KO31343 | SLC27A2 Knockout cell line (A549) | Human | SLC27A2 | 1:3~1:4 | Negative | Online Inquiry |
SLC27A2 Gene Knockout Cell Lines are specially engineered cellular models lacking the SLC27A2 gene, which encodes for a member of the solute carrier family responsible for the uptake of long-chain fatty acids in various cell types. By employing precise gene editing techniques such as CRISPR/Cas9, these cell lines allow researchers to study the effects of SLC27A2 deficiency on lipid metabolism, cellular signaling pathways, and disease mechanisms associated with metabolic disorders.
The fundamental function of SLC27A2 lies in its role as a transporter for fatty acids, critical for maintaining lipid homeostasis and energy balance in cells. By utilizing these knockout lines, scientists can delve deeper into the pathophysiology of diseases linked to impaired fatty acid transport, such as obesity, cardiovascular diseases, and certain genetic disorders. The absence of SLC27A2 in these cell lines provides an invaluable tool for elucidating compensatory mechanisms in lipid metabolism and identifying potential therapeutic targets.
The scientific importance of SLC27A2 Gene Knockout Cell Lines extends to both research and clinical applications. Researchers can conduct high-throughput screening of compounds that could restore fatty acid uptake or explore gene therapy avenues. Furthermore, these knockout lines serve as a model to investigate drug interactions and metabolic responses that could inform clinical strategies for managing lipid-related disorders.
What sets our SLC27A2 Gene Knockout Cell Lines apart is their unparalleled specificity and reliability. Developed using rigorous quality control measures, they offer consistent performance, which is critical for gaining reproducible results. In contrast to traditional cell lines that may confuse findings due to the expression of SLC27A2, these knockout models enable a clearer understanding of the gene’s role without background interference.
For researchers and clinicians alike, SLC27A2 Gene Knockout Cell Lines represent a critical advancement in the toolkit for studying lipid metabolism. Our commitment to excellence in product development and a strong foundation in molecular biology ensures that users have access to high-quality biological products that enhance the scope of their research. Embrace the innovation and reliability of our SLC27A2 Gene Knockout Cell Lines to drive groundbreaking discoveries in the field of metabolic research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.