Gene: SLC25A19
Official Full Name: solute carrier family 25 member 19provided by HGNC
Gene Summary: This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14073 | SLC25A19 Knockout cell line (HeLa) | Human | SLC25A19 | 1:3~1:6 | Negative | Online Inquiry |
KO14074 | SLC25A19 Knockout cell line (HCT 116) | Human | SLC25A19 | 1:2~1:4 | Negative | Online Inquiry |
KO14075 | SLC25A19 Knockout cell line (HEK293) | Human | SLC25A19 | 1:3~1:6 | Negative | Online Inquiry |
KO14076 | SLC25A19 Knockout cell line (A549) | Human | SLC25A19 | 1:3~1:4 | Negative | Online Inquiry |
SLC25A19 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the SLC25A19 gene, which encodes a mitochondrial transporter involved in the exchange of metabolites and nucleotides essential for cellular energy metabolism. This targeted gene knockout provides a valuable tool for researchers to elucidate the physiological roles and biochemical pathways governed by SLC25A19, particularly in the context of mitochondrial function and energy homeostasis.
The primary function of these knockout cell lines is to enable the study of the cellular and molecular consequences of SLC25A19 deficiency. By analyzing the metabolic profiles, researchers can investigate the impact on mitochondrial respiration, ATP production, and the overall cellular health of these knockout models. This information is crucial for understanding diseases related to mitochondrial dysfunction, such as certain metabolic disorders and neurological conditions.
In clinical and research settings, SLC25A19 knockout cell lines are particularly significant for developing therapeutic strategies aimed at restoring mitochondrial function or compensating for energy deficits. By utilizing these cell lines, scientists can conduct high-throughput drug screening and assess the efficacy of novel compounds intended to target mitochondrial-related disorders.
Compared to alternative genetic models, SLC25A19 gene knockout cell lines offer distinct advantages, including a highly specific and efficient gene disruption, reproducibility in experimental results, and compatibility with various in vitro assays. This specificity allows for better interpretation and understanding of the resultant phenotypes compared to non-targeted approaches, which may yield ambiguous outcomes.
The availability of SLC25A19 Gene Knockout Cell Lines is immensely valuable to researchers and clinicians who are focused on mitochondrial biology and its implications in health and disease. By providing precise models for investigation, this product empowers breakthroughs in therapeutic development and enhances our understanding of mitochondrial roles in cellular processes.
Our company is dedicated to advancing research through high-quality biological products tailored to meet the needs of the scientific community. With our expertise in genetic engineering and commitment to excellence, we provide researchers with the tools necessary to explore and innovate at the forefront of biological science.
Please note that all services are for research use only. Not intended for any clinical use.
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