Gene: SKIC8
Official Full Name: SKI8 subunit of superkiller complexprovided by HGNC
Gene Summary: WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14116 | SKIC8 Knockout cell line (HeLa) | Human | SKIC8 | 1:3~1:6 | Negative | Online Inquiry |
KO14117 | SKIC8 Knockout cell line (HCT 116) | Human | SKIC8 | 1:2~1:4 | Negative | Online Inquiry |
KO14118 | SKIC8 Knockout cell line (HEK293) | Human | SKIC8 | 1:3~1:6 | Negative | Online Inquiry |
KO14119 | SKIC8 Knockout cell line (A549) | Human | SKIC8 | 1:3~1:4 | Negative | Online Inquiry |
SKIC8 Gene Knockout Cell Lines are genetically modified cell lines designed for the targeted deletion of the SKIC8 gene, providing a powerful tool for studying gene function and the molecular mechanisms underlying various biological processes. By utilizing advanced CRISPR/Cas9 technology, SKIC8 Gene Knockout Cell Lines allow researchers to create precise knockout models that eliminate the expression of the SKIC8 protein. This directed gene disruption can reveal critical insights into gene function and reveal its role in cellular pathways.
The mechanism underlying the functionality of these cell lines is based on the introduction of specific guide RNAs alongside the Cas9 nuclease into the host cells, resulting in non-homologous end joining repairs that lead to gene knockout. This method offers high efficiency and specificity, reducing off-target effects that can confound experimental results. SKIC8 Gene Knockout Cell Lines are essential for researchers aiming to dissect complex genetic interactions and for validating the biological relevance of the SKIC8 gene in various cellular contexts.
The scientific importance of these cell lines spans multiple domains, including cancer research, developmental biology, and drug discovery. By enabling the investigation of SKIC8 function in disease models, these knockout cell lines can facilitate the identification of novel therapeutic targets and biomarkers, thereby enhancing translational research.
Compared to traditional gene-editing methods, SKIC8 Gene Knockout Cell Lines provide a streamlined and reproducible approach that enhances experimental accuracy. Their use in experimental setups offers researchers the ability to observe phenomena in isogenic backgrounds, minimizing variability that can arise from genetic drift.
For researchers, clinicians, and biotech professionals, the value of SKIC8 Gene Knockout Cell Lines lies in their ability to generate robust, reproducible data that can drive scientific discovery and innovation. Our company is committed to providing high-quality, reliable biological tools, including the SKIC8 Gene Knockout Cell Lines, and we leverage our expertise in genetic engineering to empower the scientific community in their quest for knowledge and advancement in therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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