Gene: SIX4
Official Full Name: SIX homeobox 4provided by HGNC
Gene Summary: This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22200 | SIX4 Knockout cell line (HeLa) | Human | SIX4 | 1:3~1:6 | Negative | Online Inquiry |
KO22201 | SIX4 Knockout cell line (HCT 116) | Human | SIX4 | 1:2~1:4 | Negative | Online Inquiry |
KO22202 | SIX4 Knockout cell line (HEK293) | Human | SIX4 | 1:3~1:6 | Negative | Online Inquiry |
KO22203 | SIX4 Knockout cell line (A549) | Human | SIX4 | 1:3~1:4 | Negative | Online Inquiry |
SIX4 Gene Knockout Cell Lines are genetically modified cell lines that have undergone targeted deletion of the SIX4 gene, which encodes for a transcription factor involved in various developmental and cellular processes. These cell lines are invaluable tools for investigating the role of SIX4 in cellular differentiation, tissue regeneration, and the pathological mechanisms underlying diseases.
The primary function of the SIX4 Gene Knockout Cell Lines lies in their ability to elucidate the molecular pathways regulated by the SIX4 transcription factor. By comparing the knockout lines to their wild-type counterparts, researchers can probe the gene's functions in gene expression regulation, signaling pathways, and developmental processes such as myogenesis and neurogenesis. The knockout mechanism is typically achieved through the CRISPR-Cas9 system or other gene-editing technologies that introduce precise insertions, deletions, or replacements in the genomic DNA.
The scientific importance of these cell lines extends into both basic research and clinical applications. They provide a robust model for studying the consequences of SIX4 deficiency, which has implications in conditions such as muscle dystrophies and neurodevelopmental disorders. Furthermore, the findings derived from these studies can drive the development of targeted therapies and gene editing approaches aimed at restoring normal function.
One key advantage of SIX4 Gene Knockout Cell Lines over alternative models is their specificity and reproducibility. The intentional disruption of the SIX4 gene eliminates background variation that can occur with pharmacological inhibitors or siRNA knockdowns, offering more reliable results. Additionally, these cell lines can be propagated and modified further, meaning they can be adapted to various experimental conditions or used alongside other genetic tools.
For researchers, clinicians, and biotech developers, the significance of SIX4 Gene Knockout Cell Lines is underscored by their potential to deepen our understanding of gene function and contribute to the discovery of novel therapeutic avenues. The strategic insights gained from manipulating these cell lines can lead to transformative advancements in regenerative medicine and genetic research.
Our company prides itself on its commitment to delivering high-quality biological products, such as the SIX4 Gene Knockout Cell Lines, backed by extensive expertise in cell biology and genetics. We strive to support the scientific community in driving innovation and uncovering new knowledge through precision-engineered biological tools.
Please note that all services are for research use only. Not intended for any clinical use.
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