Gene: SIGIRR
Official Full Name: single Ig and TIR domain containingprovided by HGNC
Gene Summary: Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20767 | SIGIRR Knockout cell line (HeLa) | Human | SIGIRR | 1:3~1:6 | Negative | Online Inquiry |
KO20768 | SIGIRR Knockout cell line (HCT 116) | Human | SIGIRR | 1:2~1:4 | Negative | Online Inquiry |
KO20769 | SIGIRR Knockout cell line (HEK293) | Human | SIGIRR | 1:3~1:6 | Negative | Online Inquiry |
KO20770 | SIGIRR Knockout cell line (A549) | Human | SIGIRR | 1:3~1:4 | Negative | Online Inquiry |
SIGIRR Gene Knockout Cell Lines are a sophisticated set of genetically engineered cell lines specifically designed to facilitate the study of the Single Immunoglobulin and Toll-Interleukin Receptor (SIGIRR) gene's role in immune response regulation. These knockout cell lines have been meticulously developed to ensure the complete ablation of SIGIRR gene expression, enabling researchers to investigate the gene's involvement in inflammation, immune signaling pathways, and various disease states, particularly in the context of autoimmune diseases and cancer.
The key mechanism underlying the functionality of SIGIRR Gene Knockout Cell Lines revolves around the disruption of specific signaling pathways that SIGIRR typically modulates. By creating a loss-of-function model, scientists can effectively assess how the absence of this protein influences cellular responses to stimuli such as pathogenic infections and inflammatory mediators. This understanding is vital for unraveling the complexities of immune dysregulation, paving the way for novel therapeutic strategies aimed at targeting SIGIRR-related pathways.
In research and clinical settings, these knockout cell lines are instrumental tools for elucidating the molecular mechanisms underpinning immune responses and for developing potential immunotherapeutic interventions. Their utility extends to drug discovery, where they can be employed to screen for compounds that restore normal immune function in SIGIRR-deficient models.
One of the significant advantages of utilizing SIGIRR Gene Knockout Cell Lines is their specificity and reliability as models for studying immune system dynamics. Compared to other alternatives, these lines offer a targeted approach to gene function analysis, ensuring consistent experimental outcomes that are critical for reproducibility in scientific research. Furthermore, the accessibility of these cell lines encourages broader collaboration across various fields of study.
For researchers and clinicians alike, the value of SIGIRR Gene Knockout Cell Lines lies in their ability to provide insights that are essential for targeted interventions in conditions marked by immune dysregulation. Our company prides itself on its extensive expertise in developing high-quality biological products that empower researchers to push the boundaries of molecular biology and therapeutic development. With a commitment to innovation and precision, we are dedicated to equipping the scientific community with the tools necessary to advance their research effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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