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SH3RF1 Knockout Cell Lines

Gene: SH3RF1

Official Full Name: SH3 domain containing ring finger 1provided by HGNC

Gene Summary: This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05281 SH3RF1 Knockout cell line (HeLa) Human SH3RF1 1:3~1:6 Negative Online Inquiry
KO05282 SH3RF1 Knockout cell line (HCT 116) Human SH3RF1 1:2~1:4 Negative Online Inquiry
KO05283 SH3RF1 Knockout cell line (HEK293) Human SH3RF1 1:3~1:6 Negative Online Inquiry
KO05284 SH3RF1 Knockout cell line (A549) Human SH3RF1 1:3~1:4 Negative Online Inquiry

Background

SH3RF1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the SH3RF1 gene, which encodes a binding protein involved in intracellular signaling and protein-protein interactions. These knockout cell lines serve as indispensable tools in molecular biology and biomedical research, allowing scientists to dissect the function of the SH3RF1 protein and its role in various cellular processes.

The primary function of these cell lines revolves around their ability to facilitate the study of SH3RF1-related pathways, including those involved in cell proliferation, apoptosis, and signal transduction. By eliminating the expression of SH3RF1, researchers can observe distinct phenotypic changes, elucidate compensatory mechanisms, and identify downstream signaling cascades. This comprehensive understanding is crucial for deciphering the complexities of cellular behavior in normal physiology and disease states.

Scientifically, the SH3RF1 Gene Knockout Cell Lines are pivotal in cancer research, neurobiology, and developmental biology, where aberrant signaling pathways often contribute to pathogenesis. These models enable the validation of therapeutic targets and the exploration of potential interventions, thus offering significant applications in preclinical drug development.

Compared to traditional cell models, the knockout approach offers a more precise and controlled environment to study specific gene function. The ability to establish a clear correlation between the absence of SH3RF1 and the resultant biological effects makes these cell lines superior to non-targeted knockdowns or overexpression systems.

For researchers and clinicians, the value of SH3RF1 Gene Knockout Cell Lines lies in their robustness and reproducibility, which streamline experimental design and enhance the reliability of results. This product empowers users to explore novel hypotheses and accelerate discovery in their respective fields.

Our company is committed to advancing scientific research by providing high-quality biological products, underpinned by our extensive expertise in genetic engineering and cell line development. We understand the importance of precision tools in research and strive to support the broader scientific community with exceptional offerings like the SH3RF1 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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