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SH2B2 Knockout Cell Lines

Gene: SH2B2

Official Full Name: SH2B adaptor protein 2provided by HGNC

Gene Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01738 SH2B2 Knockout cell line (HeLa) Human SH2B2 1:3~1:6 Negative Online Inquiry
KO01739 SH2B2 Knockout cell line (HCT 116) Human SH2B2 1:2~1:4 Negative Online Inquiry
KO01740 SH2B2 Knockout cell line (HEK293) Human SH2B2 1:3~1:6 Negative Online Inquiry

Background

SH2B2 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the functional roles of the SH2B2 gene, which encodes a protein involved in intracellular signaling pathways that govern various biological processes, including cell proliferation, differentiation, and metabolism. This knockout model facilitates the investigation of SH2B2’s contributions to disease mechanisms, particularly in contexts such as cancer and metabolic disorders, where the regulation of these pathways is critical.

The primary mechanism of action of SH2B2 gene knockout involves the targeted deletion of the SH2B2 gene, resulting in the absence of the protein product which alters downstream signaling cascades. Researchers can utilize these cell lines to elucidate the specific roles that SH2B2 plays in cellular responses to environmental stimuli, thus providing insights into how disturbances in these signaling pathways may lead to pathological conditions.

The scientific importance of SH2B2 Gene Knockout Cell Lines lies in their multifaceted applications, spanning basic research, drug discovery, and translational medicine. By leveraging these models, researchers can perform high-throughput screening of therapeutics aimed at restoring or compensating for the loss of SH2B2 function, offering potential targets for intervention in diseases associated with its dysregulation.

What sets SH2B2 Gene Knockout Cell Lines apart from alternative models is the precision of gene editing technology utilized in their creation, ensuring a complete and stable knockout. Unlike transient knockdown approaches that may not fully recapitulate the loss of gene function, our knockout cell lines provide consistent experimental reproducibility and reliability, making them a superior choice for rigorous scientific studies.

For researchers and clinicians, the ability to explore the specific mechanisms of SH2B2 in health and disease is invaluable, providing a pathway to novel therapeutic strategies. Our commitment to producing high-quality cell lines is backed by extensive expertise in genetic engineering and a dedication to advancing biological science. By incorporating SH2B2 Gene Knockout Cell Lines into your research, you are investing in a profound understanding of cellular signaling dynamics and the potential for impactful scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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