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SGSM2 Knockout Cell Lines

Gene: SGSM2

Official Full Name: small G protein signaling modulator 2provided by HGNC

Gene Summary: The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32551 SGSM2 Knockout cell line (HeLa) Human SGSM2 1:3~1:6 Negative Online Inquiry
KO32552 SGSM2 Knockout cell line (HCT 116) Human SGSM2 1:2~1:4 Negative Online Inquiry
KO32553 SGSM2 Knockout cell line (HEK293) Human SGSM2 1:3~1:6 Negative Online Inquiry
KO32554 SGSM2 Knockout cell line (A549) Human SGSM2 1:3~1:4 Negative Online Inquiry

Background

SGSM2 Gene Knockout Cell Lines are genetically engineered cell lines characterized by the targeted disruption of the SGSM2 gene, which encodes for the small GTPase known to play a critical role in various cellular processes including proliferation, differentiation, and cytoskeletal organization. By utilizing CRISPR-Cas9 technology, these cell lines provide a robust platform for elucidating the specific functions of SGSM2 and its downstream signaling pathways in a controlled environment.

The primary mechanism of action involves the precise editing of the SGSM2 gene, leading to a loss of function that allows researchers to observe changes in cellular behavior and gene expression patterns compared to wild-type controls. This knockout model is invaluable for dissecting the pathological roles of SGSM2 in disease contexts, such as cancer, neurodegenerative disorders, and metabolic diseases.

In scientific and clinical research settings, SGSM2 Gene Knockout Cell Lines serve as an essential tool for functional studies, drug screening, and mechanism-of-action investigations. The ability to specifically knockout genes allows researchers to isolate and understand the contributions of SGSM2, potentially identifying new therapeutic targets and biomarkers for disease intervention.

One of the standout advantages of our SGSM2 Gene Knockout Cell Lines is their high specificity and efficiency, enabling precise gene disruption with minimal off-target effects—an enhancement compared to conventional knockout models or transgenic approaches. Furthermore, our cell lines are derived from multiple biological backgrounds, increasing their relevance across different tissue types and conditions, thus broadening their application scope.

For researchers and clinicians, the value of SGSM2 Gene Knockout Cell Lines lies in their potential to accelerate discoveries in gene function and therapeutics. They are especially beneficial for studies that require reliable replication and reproducibility, crucial for advancing scientific knowledge and developing innovative treatments.

With our company's extensive expertise in molecular biology and genetic engineering, we are committed to providing high-quality biological products that empower researchers to make groundbreaking advancements in their fields. Our facilities and experienced team ensure that our SGSM2 Gene Knockout Cell Lines meet rigorous standards for quality and performance, allowing users to focus on their research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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