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SGO2 Knockout Cell Lines

Gene: SGO2

Official Full Name: shugoshin 2provided by HGNC

Gene Summary: Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21986 SGO2 Knockout cell line (HeLa) Human SGO2 1:3~1:6 Negative Online Inquiry
KO21987 SGO2 Knockout cell line (HCT 116) Human SGO2 1:2~1:4 Negative Online Inquiry
KO21988 SGO2 Knockout cell line (HEK293) Human SGO2 1:3~1:6 Negative Online Inquiry
KO21989 SGO2 Knockout cell line (A549) Human SGO2 1:3~1:4 Negative Online Inquiry

Background

SGO2 Gene Knockout Cell Lines are precision-engineered cellular models designed to facilitate in-depth studies of the SGO2 gene, which plays a critical role in mitotic regulation and genomic stability. These knockout cell lines enable researchers to completely eliminate the SGO2 gene's expression, allowing for a detailed investigation of its function and the mechanistic pathways it influences during cellular division and overall genomic health.

The core functionality of SGO2 Gene Knockout Cell Lines lies in their ability to provide a functional loss-of-gene context. The knockout is achieved through CRISPR/Cas9 technology, which introduces targeted mutations into the SGO2 gene. This disruption allows researchers to analyze phenotypic alterations, cell cycle progression, and the impact on DNA repair mechanisms, thus offering insights into various diseases linked to chromosomal instability, including cancer.

The scientific importance of these cell lines extends to both basic research and translational applications, as they provide a robust platform to elucidate the molecular underpinnings of oncogenesis and identify potential therapeutic targets. In clinical settings, understanding the role of SGO2 is crucial for developing targeted interventions for malignancies associated with its dysregulation.

Compared to alternative models, the SGO2 Gene Knockout Cell Lines offer enhanced specificity and reliability, ensuring that the observed effects can be directly attributed to the loss of SGO2 function. These cell lines are validated for consistent performance, significantly reducing variability and improving reproducibility in experimental outcomes.

For researchers and clinicians striving to deepen their understanding of mitotic mechanisms or to develop novel cancer therapies, SGO2 Gene Knockout Cell Lines provide an essential and valuable tool. Their unique capabilities underscore the importance of employing precise biological models to drive scientific innovation.

Our company prides itself on its expertise in developing high-quality, reliable biological products tailored for advanced research applications. The SGO2 Gene Knockout Cell Lines exemplify our commitment to providing cutting-edge resources that empower the scientific community in their quest for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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