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SFXN4 Knockout Cell Lines

Gene: SFXN4

Official Full Name: sideroflexin 4provided by HGNC

Gene Summary: This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30363 SFXN4 Knockout cell line (HeLa) Human SFXN4 1:3~1:6 Negative Online Inquiry
KO30364 SFXN4 Knockout cell line (HCT 116) Human SFXN4 1:2~1:4 Negative Online Inquiry
KO30365 SFXN4 Knockout cell line (HEK293) Human SFXN4 1:3~1:6 Negative Online Inquiry
KO30366 SFXN4 Knockout cell line (A549) Human SFXN4 1:3~1:4 Negative Online Inquiry

Background

SFXN4 Gene Knockout Cell Lines represent a groundbreaking advancement in genetic research and functional genomics. These specialized cell lines are engineered to lack the SFXN4 gene, a critical player in iron-sulfur cluster assembly and mitochondrial function. By creating these knockout models, researchers can investigate the roles of SFXN4 in cellular metabolism, disease pathology, and gene interaction networks, facilitating a deeper understanding of cellular homeostasis and mitochondrial disorders.

The primary function of SFXN4 Gene Knockout Cell Lines is to enable the examination of the phenotypic consequences arising from the absence of the SFXN4 gene. This is achieved through targeted CRISPR-Cas9 techniques that effectively disrupt the gene's sequence, thereby allowing for the assessment of downstream effects on metabolic pathways, oxidative stress responses, and iron-sulfur cluster biogenesis. Given the gene's implications in various diseases, including neurodegenerative disorders and certain cancers, these models are invaluable for elucidating disease mechanisms and developing novel therapeutic strategies.

The scientific importance of SFXN4 Gene Knockout Cell Lines is underscored by their applications in both basic and translational research. They provide researchers with an essential tool for exploring gene function, validating drug targets, and creating disease-relevant cellular models. In clinical settings, these knockout cell lines can aid in the evaluation of potential treatments, promoting the development of targeted interventions that could enhance patient outcomes.

In comparison to alternative models, SFXN4 Gene Knockout Cell Lines offer unique advantages, including high specificity in gene targeting, reproducibility in experimental results, and a robust platform for high-throughput screening. These features contribute to streamlined workflows and more reliable data, ensuring that researchers can draw significant conclusions from their experiments.

For researchers, clinicians, and biotech companies alike, the value of SFXN4 Gene Knockout Cell Lines lies in their capacity to illuminate the complexities of gene function and disease, providing a foundation for innovative research and therapeutic advancements. As a trusted provider in the field of genetic engineering, our company prides itself on delivering high-quality biological products, equipped with the expertise and technical support needed to facilitate significant scientific breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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