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SFRP4 Knockout Cell Lines

Gene: SFRP4

Official Full Name: secreted frizzled related protein 4provided by HGNC

Gene Summary: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35472 SFRP4 Knockout cell line (A549) Human SFRP4 1:3~1:4 Negative Online Inquiry

Background

SFRP4 Gene Knockout Cell Lines represent a powerful tool for researchers studying the intricate roles of the secreted frizzled-related protein 4 (SFRP4) in various biological processes. These cell lines are genetically modified to eliminate the expression of the SFRP4 gene, allowing scientists to investigate the consequences of its absence on cellular behavior, signaling pathways, and interactions with extracellular environments.

The primary function of SFRP4 involves its role as an antagonist in the Wnt signaling pathway, which is crucial for regulating cell proliferation, differentiation, and embryonic development. By utilizing SFRP4 knockout cell lines, researchers can manipulate and observe the downstream effects of Wnt signaling disruptions, thereby acquiring unique insights into processes such as oncogenesis, stem cell maintenance, and tissue regeneration. These knockout models offer a highly controlled environment to dissect molecular mechanisms, essential for advancing our understanding of both normal physiology and disease states.

The scientific significance of SFRP4 Gene Knockout Cell Lines spans various applications, particularly in cancer research, regenerative medicine, and developmental biology. Their capacity to elucidate the nuances of Wnt signaling and its interplay with other pathways makes these cell lines invaluable for drug discovery and therapeutic development.

Unlike traditional cell lines, SFRP4 knockout models provide a distinguished advantage by enabling the direct observation of gene loss effects without the confounding variables inherent in wild-type systems. This specificity enhances experimental reproducibility and reliability, making them a premium choice over alternatives that lack genetic precision.

For researchers and clinicians focused on cellular pathways and therapeutic targets, SFRP4 Gene Knockout Cell Lines are instrumental in both foundational and applied research. The potential to derive actionable insights from these models underscores their importance in modern biomedical research.

Our company is dedicated to providing high-quality, genetically engineered cell lines and supporting researchers with exceptional technical expertise and resources. We strive to empower the scientific community in their quests to unravel complex biological phenomena.

Please note that all services are for research use only. Not intended for any clinical use.

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