Gene: SEPTIN1
Official Full Name: septin 1provided by HGNC
Gene Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38236 | SEPTIN1 Knockout cell line (HeLa) | Human | SEPTIN1 | 1:3~1:6 | Negative | Online Inquiry |
KO38237 | SEPTIN1 Knockout cell line (HEK293) | Human | SEPTIN1 | 1:3~1:6 | Negative | Online Inquiry |
SEPTIN1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed for studying the functions and mechanisms of the SEPTIN1 gene, which encodes a protein that plays a pivotal role in various cellular processes, including cytoskeletal dynamics, cell division, and membrane trafficking. By utilizing CRISPR-Cas9 technology, these knockout cell lines offer a robust platform for elucidating the contributions of SEPTIN1 to cellular architecture and pathology.
These cell lines function by completely disrupting the expression of the SEPTIN1 gene, enabling researchers to investigate the consequent phenotypic changes and molecular pathways that may be affected. Numerous studies have linked septin proteins to important cellular processes; therefore, these cell lines are indispensable for exploring their role in disease models, particularly in cancer progression and neurodegenerative disorders.
From a scientific perspective, SEPTIN1 Gene Knockout Cell Lines serve as invaluable tools for both basic and translational research. Their application extends to drug development, where potential therapeutic strategies can be tested against the backdrop of altered septin function. Importantly, researchers can utilize these models to explore compensatory mechanisms in cellular function, providing insights into gene interactions and network dynamics.
Compared to traditional wild-type cell lines, SEPTIN1 knockout models offer distinct advantages such as enhanced specificity in functional studies, a clearer understanding of genetic contributions to physiological and pathological states, and a more defined platform for screening drug efficacy. Furthermore, these cell lines are meticulously validated for consistent performance, ensuring reliability in various experimental contexts.
For researchers and clinicians engaged in cellular biology, molecular genetics, or pharmacology, these knockout cell lines represent a critical resource for advancing understanding of septin-related diseases. Our company prides itself on providing high-quality, rigorously-tested biological products to facilitate cutting-edge research and contribute to significant scientific discoveries. With a dedicated commitment to innovation, we enhance the capabilities of the scientific community in exploring complex biological questions and accelerating therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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