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SELENOS Knockout Cell Lines

Gene: SELENOS

Official Full Name: selenoprotein Sprovided by HGNC

Gene Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20639 SELENOS Knockout cell line (HeLa) Human SELENOS 1:3~1:6 Negative Online Inquiry
KO20640 SELENOS Knockout cell line (HCT 116) Human SELENOS 1:2~1:4 Negative Online Inquiry
KO20641 SELENOS Knockout cell line (HEK293) Human SELENOS 1:3~1:6 Negative Online Inquiry
KO20642 SELENOS Knockout cell line (A549) Human SELENOS 1:3~1:4 Negative Online Inquiry

Background

SELENOS Gene Knockout Cell Lines are sophisticated cellular models specifically engineered to lack the SELENOS gene, which encodes a selenoprotein implicated in redox homeostasis and antioxidant defense. These cell lines are pivotal tools for understanding the intricate roles of selenium-related biology in various cellular processes. By employing CRISPR-Cas9 or similar gene-editing technologies, SELENOS knockout lines facilitate in-depth investigations into the gene's function, elucidating its contribution to cellular stress responses, proliferation, differentiation, and apoptosis.

The core function of these knockout cell lines hinges on the loss of SELENOS expression, enabling researchers to create experimental conditions free from the gene's influence. This loss allows for the dissection of compensatory mechanisms and pathways that may be activated in the absence of SELENOS, providing invaluable insights into cellular resilience and vulnerability in both physiological and pathological states. Such knockout models are particularly invaluable in cancer research, neurobiology, and studies focused on metabolic disorders where oxidative stress plays a pivotal role.

The scientific importance of SELENOS Gene Knockout Cell Lines extends to various applications in both research and clinical laboratories. They serve as essential resources for drug discovery, toxicity testing, and functional genomics studies, where delineating the effects of selenium deficiency can lead to novel therapeutic interventions. Compared to traditional cell lines, these engineered models offer a more precise and targeted approach to studying the gene's function, advancing the field of selenium biology.

Users can depend on SELENOS Gene Knockout Cell Lines not only for their specificity and reliability but also for their ability to yield reproducible results that are crucial for high-stakes research settings. They allow researchers to explore uncharted territories in gene function and regulation, making them a unique offering in the current market.

Our company is committed to providing high-quality, biologically relevant products that empower scientific inquiry. With a focus on innovation and precision, we ensure that our offerings, including SELENOS Gene Knockout Cell Lines, equip researchers and clinicians with the tools needed to advance their studies and improve health outcomes through a deeper understanding of molecular mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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