Gene: SELENON
Official Full Name: selenoprotein Nprovided by HGNC
Gene Summary: This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20478 | SELENON Knockout cell line (HeLa) | Human | SELENON | 1:3~1:6 | Negative | Online Inquiry |
KO20479 | SELENON Knockout cell line (HCT 116) | Human | SELENON | 1:2~1:4 | Negative | Online Inquiry |
KO20480 | SELENON Knockout cell line (HEK293) | Human | SELENON | 1:3~1:6 | Negative | Online Inquiry |
KO20481 | SELENON Knockout cell line (A549) | Human | SELENON | 1:3~1:4 | Negative | Online Inquiry |
SELENON Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the SELENON gene, which plays a critical role in selenoprotein synthesis and antioxidant defense mechanisms. These cell lines are created using targeted gene editing techniques such as CRISPR/Cas9, ensuring precise deletion or inactivation of the SELENON gene. The absence of SELENON in these cell lines provides a unique platform for researchers to study cellular responses to oxidative stress, selenium-dependent processes, and mitochondrial function under various physiological and pathological conditions.
The functionality of SELENON knockouts lies in their ability to simulate conditions of compromised selenoprotein expression, enabling scientists to explore the gene's contributions to cellular metabolism, apoptosis, and disease mechanisms, particularly in the context of degenerative diseases or cancer. These cell lines serve as invaluable tools in elucidating the roles of selenium in health and disease, advancing our understanding of its critical biological functions.
In research and clinical settings, SELENON Gene Knockout Cell Lines are indispensable for both fundamental studies and applied research such as drug discovery and toxicity testing. Their unique ability to mimic specific disease states allows for more relevant experimental models that can streamline the development of therapeutic interventions.
Compared to alternative models, SELENON knockouts offer unprecedented specificity concerning selenium metabolism and are more representative of human biological responses, thus enhancing the translational potential of research findings. Their reliability, ease of use, and compatibility with various experimental methods set them apart as superior tools for studying selenoprotein biology.
Utilizing SELENON Gene Knockout Cell Lines will empower researchers and clinicians to uncover novel insights into selenium-related mechanisms, driving progress towards innovative health solutions. Our company is backed by extensive expertise in bioengineering and genetic editing, ensuring that we provide high-quality, reproducible biological products that meet the rigorous demands of modern research.
Please note that all services are for research use only. Not intended for any clinical use.
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