Gene: SELENOH
Official Full Name: selenoprotein Hprovided by HGNC
Gene Summary: This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14239 | SELENOH Knockout cell line (HeLa) | Human | SELENOH | 1:3~1:6 | Negative | Online Inquiry |
KO14240 | SELENOH Knockout cell line (HCT 116) | Human | SELENOH | 1:2~1:4 | Negative | Online Inquiry |
KO14241 | SELENOH Knockout cell line (HEK293) | Human | SELENOH | 1:3~1:6 | Negative | Online Inquiry |
KO14242 | SELENOH Knockout cell line (A549) | Human | SELENOH | 1:3~1:4 | Negative | Online Inquiry |
SELENOH Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the SELENOH gene, which encodes for a selenium-binding protein implicated in various biological processes, including oxidative stress response and cellular signaling. These knockout cell lines serve as invaluable tools for researchers seeking to elucidate the functional role of SELENOH in physiological and pathological contexts.
The primary mechanism at work within SELENOH knockout lines involves the targeted inactivation of the SELENOH gene through advanced CRISPR/Cas9 gene-editing technology. By effectively silencing this gene, researchers can study the resulting phenotypic changes that may impact processes such as apoptosis, growth regulation, and cellular metabolism. This model allows for a controlled approach to investigate the gene's contribution to conditions such as cancer, neurodegenerative diseases, and inflammatory responses.
The scientific importance of SELENOH Gene Knockout Cell Lines cannot be overstated, particularly in research settings focused on oxidative stress and disease progression. These cell lines provide a robust platform for drug discovery, biomarker identification, and the investigation of therapeutic targets, thus contributing to improved understanding of complex biological mechanisms.
Compared to alternative cellular models, SELENOH knockout lines offer a specific and precise gene disruption, enabling researchers to minimize confounding variables. The knockout approach boasts reproducibility and consistency, ensuring reliability in experimental outcomes. Consequently, researchers can draw more accurate conclusions, ultimately enhancing the translational potential of their findings.
For researchers and clinicians alike, investing in SELENOH Gene Knockout Cell Lines represents a strategic advantage to uncover novel insights into SELENOH-related pathways, paving the way for advancements in targeted therapies. With a commitment to delivering high-quality, scientifically relevant products, our company harnesses leading-edge genomic technology and expertise to support the scientific community in their quest for innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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