Gene: SEC24D
Official Full Name: SEC24 homolog D, COPII coat complex componentprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32603 | SEC24D Knockout cell line (HeLa) | Human | SEC24D | 1:3~1:6 | Negative | Online Inquiry |
KO32604 | SEC24D Knockout cell line (HCT 116) | Human | SEC24D | 1:2~1:4 | Negative | Online Inquiry |
KO32605 | SEC24D Knockout cell line (HEK293) | Human | SEC24D | 1:3~1:6 | Negative | Online Inquiry |
KO32606 | SEC24D Knockout cell line (A549) | Human | SEC24D | 1:3~1:4 | Negative | Online Inquiry |
SEC24D Gene Knockout Cell Lines represent a cutting-edge tool in cellular and molecular biology research, specifically designed to investigate the role of the SEC24D gene and its product in protein transport and secretion processes. These genetically engineered cell lines have had the SEC24D gene functionally inactivated, allowing researchers to study the resultant phenotypic effects and the underlying molecular mechanisms related to endoplasmic reticulum (ER) to Golgi transport and Golgi organization.
The primary function of the SEC24D gene revolves around encoding a component of the COPII complex, which is essential for the transport of proteins from the ER to the Golgi apparatus. By knocking out SEC24D, researchers gain insight into the protein sorting processes and can elucidate potential pathways, such as those involved in secretory and membranous structures, that may be altered. This mechanistic understanding is crucial for studies related to various diseases, particularly those associated with secretion pathways, such as diabetes and neurodegenerative disorders.
In clinical and research settings, SEC24D Gene Knockout Cell Lines serve as a valuable platform for drug discovery and development, cellular signaling studies, and the investigation of metabolic pathways. Their relevance spans biochemical, pharmaceutical, and genetic studies geared toward therapeutic interventions. Compared to other knockout models, the SEC24D cell lines provide a specific context where the impact of impaired protein transport can be directly assessed, yielding clearer insights into cellular health and disease mechanisms.
The unique advantage of our SEC24D Gene Knockout Cell Lines lies in their precise genetic modification, which enhances reproducibility and specificity in experimental setups. Additionally, these cell lines are supported by a robust background of molecular characterization, ensuring reliability in experimental outcomes.
For researchers and clinicians aiming to deepen their understanding of cellular transport mechanisms and their implications in health and disease, our SEC24D Gene Knockout Cell Lines are an invaluable resource. With years of expertise in the development of high-quality genetic models, our company is dedicated to providing innovative solutions to facilitate impactful scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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