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SDCBP Knockout Cell Lines

Gene: SDCBP

Official Full Name: syndecan binding proteinprovided by HGNC

Gene Summary: The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03913 SDCBP Knockout cell line (HeLa) Human SDCBP 1:3~1:6 Negative Online Inquiry
KO03914 SDCBP Knockout cell line (HCT 116) Human SDCBP 1:2~1:4 Negative Online Inquiry
KO03915 SDCBP Knockout cell line (HEK293) Human SDCBP 1:3~1:6 Negative Online Inquiry
KO03916 SDCBP Knockout cell line (A549) Human SDCBP 1:3~1:4 Negative Online Inquiry

Background

SDCBP Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, designed specifically for the targeted disruption of the SDCBP (syndecan-binding protein) gene. By utilizing CRISPR-Cas9 genome editing technology, these cell lines facilitate precise genetic modifications, enabling researchers to investigate the functional outcomes of SDCBP deficiency. The creation of these knockout models allows for the elucidation of genetic pathways and cellular processes influenced by SDCBP, providing invaluable insights into its role in cell signaling, growth, and adhesion.

The key mechanism underpinning SDCBP Gene Knockout Cell Lines is the targeted introduction of double-strand breaks in the DNA at specific loci, which the cell repairs through non-homologous end joining (NHEJ), typically resulting in insertions or deletions that lead to gene inactivation. This technique allows scientists to model disease states and test therapeutic interventions that could modulate SDCBP activity, making them crucial in research related to cancer metastasis, developmental biology, and regenerative medicine.

The scientific importance of these knockout cell lines is profound, with applications spanning basic research to clinical investigations. They serve as platforms for drug screening, biomarker identification, and studying gene function in regulated environments. Researchers benefit significantly from the availability of these cell lines, as they provide a reproducible and reliable model to investigate the etiology of SDCBP-associated conditions.

Compared to traditional knockout strategies, which may involve time-consuming and imprecise methods such as random integration or homozygous breeding, SDCBP Gene Knockout Cell Lines offer a refined, quicker process that significantly reduces labor and resources. Additionally, these cell lines can be readily engineered to carry reporter genes, facilitating real-time monitoring of gene expression and cellular behavior.

For investigators and clinicians seeking to deepen their understanding of gene function, exploring new therapeutic avenues, or validating hypotheses related to SDCBP, these knockout models are an indispensable asset. Moreover, our company prides itself on its extensive expertise in genetic engineering and commitment to quality, ensuring that our SDCBP Gene Knockout Cell Lines meet the rigorous standards required for impactful scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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