Gene: SCG2
Official Full Name: secretogranin IIprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07046 | SCG2 Knockout cell line (HeLa) | Human | SCG2 | 1:3~1:6 | Negative | Online Inquiry |
KO07047 | SCG2 Knockout cell line (HCT 116) | Human | SCG2 | 1:2~1:4 | Negative | Online Inquiry |
KO07048 | SCG2 Knockout cell line (A549) | Human | SCG2 | 1:3~1:4 | Negative | Online Inquiry |
SCG2 Gene Knockout Cell Lines are genetically engineered cell lines that have been meticulously designed to disrupt the expression of the SCG2 (Secretogranin II) gene. This gene plays a critical role in the neuroendocrine secretory pathway and is known to be involved in various physiological processes, including hormone secretion and synaptic transmission. By using CRISPR-Cas9 or similar genomic editing technologies, these cell lines enable researchers to explore the functional impact of SCG2 loss, facilitating investigations into its role in neurobiology, endocrinology, and cancer research.
The primary function of SCG2 Gene Knockout Cell Lines is to act as a model for studying the cellular and molecular consequences of SCG2 disruption. This allows for a detailed understanding of its involvement in the secretion of neuropeptides and neurotransmitters, as well as its possible link to various disorders, including psychological conditions and neurodegenerative diseases. In these cell lines, loss of SCG2 expression can lead to observable changes in secretion dynamics, cell signaling pathways, and overall cellular health.
The scientific importance of SCG2 Gene Knockout Cell Lines extends into both research and clinical applications. In research settings, they are invaluable for dissecting the pathophysiological mechanisms underpinning diseases associated with SCG2 dysfunction. Additionally, they can be employed in drug discovery efforts aimed at identifying novel therapeutic agents that target SCG2-related pathways.
What sets SCG2 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification, which ensures a more accurate representation of SCG2-related biological processes compared to traditional knockout methods. Furthermore, these cell lines offer reproducibility and consistency, making them essential for high-quality, credible results across multiple experiments.
For researchers and clinicians, the availability of SCG2 Gene Knockout Cell Lines represents an opportunity to unlock new insights into neuroendocrine functions and their clinical implications. This product not only enhances the understanding of SCG2 in health and disease but also catalyzes the identification of potential therapeutic targets.
Our company prides itself on pioneering cutting-edge genomic technologies and providing researchers with high-quality biological products, including expertly developed gene knockout cell lines like those for SCG2. With our commitment to scientific excellence and innovation, we empower the scientific community to drive meaningful advancements in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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