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SCAP Knockout Cell Lines

Gene: SCAP

Official Full Name: SREBF chaperoneprovided by HGNC

Gene Summary: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00208 SCAP gRNA5-gRNA6 KO plasmid SCAP $850
GP00229 SCAP gRNA1-gRNA2 KO plasmid SCAP $850
GP00248 SCAP gRNA1-gRNA2 KO plasmid SCAP $850
KO03889 SCAP Knockout cell line (HeLa) Human SCAP 1:3~1:6 Negative Online Inquiry
KO03890 SCAP Knockout cell line (HCT 116) Human SCAP 1:2~1:4 Negative Online Inquiry
KO03891 SCAP Knockout cell line (HEK293) Human SCAP 1:3~1:6 Negative Online Inquiry
KO03892 SCAP Knockout cell line (A549) Human SCAP 1:3~1:4 Negative Online Inquiry

Background

SCAP Gene Knockout Cell Lines are specially engineered cellular models developed to facilitate the study of the Sterol Regulatory Element-Binding Protein (SREBP) pathway, critical in lipid metabolism and homeostasis. These cell lines have been meticulously designed using CRISPR-Cas9 gene editing technology to eliminate the function of the SCAP gene, which encodes a protein that plays a vital role in cholesterol and fatty acid synthesis regulation. By employing these knockout cell lines, researchers can observe the physiological effects of SCAP depletion, unveiling the intricate interactions within lipid metabolic pathways.

The unique mechanism of these cell lines allows scientists to investigate how the absence of SCAP alters cellular responses to sterol levels, correlating to various metabolic disorders, including obesity and atherosclerosis. In both research and clinical applications, SCAP Gene Knockout Cell Lines serve as invaluable tools for elucidating the molecular mechanisms underlying lipid-related diseases and assessing potential therapeutic targets.

One of the primary advantages of our SCAP Gene Knockout Cell Lines is their robustness and reproducibility, exceeding similar offerings on the market. Their validated background ensures that researchers attain consistent and reliable results, facilitating rigorous experimental designs compared to wild-type or less characterized cell models. Additionally, these lines enable high-throughput screening capabilities, thus accelerating the pace of discovery in lipid metabolism research.

Overall, the value of SCAP Gene Knockout Cell Lines cannot be overstated; by empowering researchers and clinicians with advanced tools for studying metabolic diseases, they offer a profound opportunity to contribute to groundbreaking discoveries and therapeutic strategies. With years of expertise in biological products and a commitment to scientific innovation, our company is dedicated to providing high-quality research tools like the SCAP Gene Knockout Cell Lines to support the continuous advancement of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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