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SBF1 Knockout Cell Lines

Gene: SBF1

Official Full Name: SET binding factor 1provided by HGNC

Gene Summary: This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00603 SBF1 gRNA10 KO plasmid SBF1 $850
KO00854 SBF1 Knockout cell line(293T) Human SBF1 1:3~1:6 Negative Online Inquiry
KO14343 SBF1 Knockout cell line (HeLa) Human SBF1 1:3~1:6 Negative Online Inquiry
KO14344 SBF1 Knockout cell line (HCT 116) Human SBF1 1:2~1:4 Negative Online Inquiry
KO14345 SBF1 Knockout cell line (HEK293) Human SBF1 1:3~1:6 Negative Online Inquiry
KO14346 SBF1 Knockout cell line (A549) Human SBF1 1:3~1:4 Negative Online Inquiry

Background

SBF1 Gene Knockout Cell Lines are specialized cellular models in which the SBF1 gene, implicated in gene regulation and various cellular processes, has been effectively disrupted or "knocked out." These engineered cell lines serve as valuable tools for researchers investigating the biological roles of SBF1, including its impact on cell proliferation, differentiation, and response to environmental stressors. By creating SBF1 knockout models, scientists can elucidate the gene's functional contributions and potential mechanisms underlying various diseases.

The primary function of SBF1 is believed to involve the regulation of transcriptional networks, particularly in the context of hematopoietic and immune responses. The knockout of this gene allows researchers to explore its pathways and interactions without the confounding effects of SBF1 expression. Through loss-of-function studies, scientists can analyze downstream signaling pathways, gene expression profiles, and phenotypic characteristics in response to various stimuli, supporting both basic and applied research initiatives.

In clinical settings, SBF1 knockout cell lines offer numerous applications, including drug efficacy testing, understanding disease mechanisms, and the development of therapeutic strategies. These cell lines can also serve as platforms for high-throughput screening of potential therapeutics aimed at pathways influenced by SBF1. The ability to model specific genetic alterations enhances translational research by bridging fundamental science with clinical implications.

One of the key advantages of SBF1 Gene Knockout Cell Lines is their precision and specificity compared to traditional silencing methods like siRNA. These knockout models provide a stable, consistent system for long-term studies, reducing variability and increasing reproducibility. Furthermore, they can be utilized in a wide range of experimental setups, from molecular assays to in vivo models, broadening their utility across disciplines.

For researchers and clinicians, the value of SBF1 Gene Knockout Cell Lines lies in their capacity to deliver critical insights into the functional dynamics of the SBF1 gene. The ability to dissect complex biological networks will facilitate the discovery of novel therapeutic targets and improve understanding of diseases associated with SBF1 dysregulation.

At [Your Company Name], we specialize in developing high-quality biological products, including knockout cell lines that are rigorously validated for performance and reliability. By investing in our products, researchers can leverage our expertise to advance their studies and contribute meaningfully to scientific advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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