Gene: RUBCN
Official Full Name: rubicon autophagy regulatorprovided by HGNC
Gene Summary: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32880 | RUBCN Knockout cell line (HeLa) | Human | RUBCN | 1:3~1:6 | Negative | Online Inquiry |
KO32881 | RUBCN Knockout cell line (HCT 116) | Human | RUBCN | 1:2~1:4 | Negative | Online Inquiry |
KO32882 | RUBCN Knockout cell line (HEK293) | Human | RUBCN | 1:3~1:6 | Negative | Online Inquiry |
KO32883 | RUBCN Knockout cell line (A549) | Human | RUBCN | 1:3~1:4 | Negative | Online Inquiry |
RUBCN Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the RUBCN gene, which encodes a critical protein involved in various biological processes, including cellular response to stress and apoptosis regulation. These cell lines serve as an invaluable tool for researchers aiming to dissect the role of RUBCN in cellular functions, disease mechanisms, and potential therapeutic targets.
The primary function of RUBCN Gene Knockout Cell Lines hinges on the systematic silencing of RUBCN gene expression through technologies such as CRISPR-Cas9 or homologous recombination. This knockout approach enables researchers to elucidate the protein’s biological pathways, allowing for an in-depth analysis of its impact on cell signaling, survival, and differentiation processes. By comparing the knockout cells to their wild-type counterparts, scientists can readily observe phenotypic and molecular alterations, leading to a better understanding of the gene’s function in various physiological and pathological contexts.
The scientific importance of these cell lines is underscored by their wide-ranging applications in both research and clinical settings. They are particularly useful for exploring oncogenesis, neurodegenerative diseases, and metabolic disorders where RUBCN has been implicated. Furthermore, such models can facilitate drug discovery processes by allowing for the screening of potential pharmacological agents targeting the pathways associated with RUBCN deficiency.
One significant advantage of using RUBCN Gene Knockout Cell Lines is their specificity and reproducibility, providing a much clearer picture of gene function compared to traditional methods such as knockdown approaches, which can yield variable results due to residual expression. Moreover, these cell lines enable the study of gene function in a controlled environment, reducing confounding variables and allowing for precise experimental design.
For researchers, clinicians, and pharmaceutical developers seeking innovative solutions to advance understanding in genetics and pathology, RUBCN Gene Knockout Cell Lines present a robust option for elucidating the complexities of gene function and disease processes. Our company is dedicated to providing high-quality, ready-to-use cell lines supported by extensive in-house expertise, ensuring that your research can progress swiftly and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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