Gene: RPUSD3
Official Full Name: RNA pseudouridine synthase D3provided by HGNC
Gene Summary: This gene encodes a protein that functions in the assembly of the mitochondrial ribosome by adding a pseudouridine group to 16S rRNA. Loss of this gene results in causes defects in mitochondrial protein production. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14418 | RPUSD3 Knockout cell line (HeLa) | Human | RPUSD3 | 1:3~1:6 | Negative | Online Inquiry |
KO14419 | RPUSD3 Knockout cell line (HCT 116) | Human | RPUSD3 | 1:2~1:4 | Negative | Online Inquiry |
KO14420 | RPUSD3 Knockout cell line (HEK293) | Human | RPUSD3 | 1:3~1:6 | Negative | Online Inquiry |
KO14421 | RPUSD3 Knockout cell line (A549) | Human | RPUSD3 | 1:3~1:4 | Negative | Online Inquiry |
RPUSD3 Gene Knockout Cell Lines represent a pioneering biological innovation designed to facilitate the detailed study of the RPUSD3 gene's role in cellular processes. These cell lines are genetically engineered to exhibit a complete knockout of the RPUSD3 gene, providing researchers with a powerful tool for investigating the gene's functions in various biological contexts, including cancer biology, neurobiology, and cellular stress response.
The primary mechanism of action involves the targeted deletion of the RPUSD3 gene, which is crucial for understanding its contribution to RNA metabolism and mitochondrial function. By utilizing CRISPR-Cas9 or other gene-editing technologies, these cell lines enable researchers to systematically analyze the downstream effects of RPUSD3 loss on cellular signaling pathways, gene expression, and overall cell viability. This ability to dissect the gene's impact at both molecular and phenotypic levels is essential for elucidating the mechanisms underlying associated diseases.
Scientific importance is underscored by RPUSD3's involvement in critical pathways, making these knockout cell lines invaluable in both research and clinical settings. They can be employed in drug discovery, toxicity testing, and the development of therapeutic strategies aimed at restoring normal cellular functions in diseases where RPUSD3 dysregulation is observed.
Compared to alternative models such as transient knockdown cell systems or whole-animal models, RPUSD3 Gene Knockout Cell Lines offer enhanced stability and reproducibility in experimental results. They allow for long-term studies, enabling consistent assessment of gene function without the variable influences associated with temporary perturbations.
For researchers and clinicians focusing on genetic pathways, these knockout lines provide an unprecedented opportunity to advance scientific understanding and therapeutic approaches, ultimately driving innovations in precision medicine. Backed by our proven expertise in genetic engineering and cell line development, we are committed to providing high-quality biological products designed to meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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