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RORA Knockout Cell Lines

Gene: RORA

Official Full Name: RAR related orphan receptor Aprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00519 RORA Knockout cell line (HEK293) Human RORA 1:3~1:6 Negative Online Inquiry
KO06959 RORA Knockout cell line (A549) Human RORA 1:3~1:4 Negative Online Inquiry

Background

RORA Gene Knockout Cell Lines are specially engineered mammalian cell lines in which the RORA gene has been systematically disrupted through targeted gene editing techniques such as CRISPR/Cas9. RORA (retinoic acid receptor-related orphan receptor alpha) plays a vital role in regulating various physiological processes, including circadian rhythm, immune response, and metabolism. By generating RORA gene knockout cell lines, researchers can study the gene's functional contributions to these complex mechanisms in a controlled laboratory environment.

The key functionality of RORA Gene Knockout Cell Lines lies in their ability to delineate the specific biological pathways influenced by RORA. Researchers can utilize these cell lines to investigate the downstream effects of RORA deletion, enabling them to unpack its role in pathologies such as neurodegenerative diseases, metabolic disorders, and immune dysfunction. This targeted approach enhances the clarity and precision of experimental outcomes, paving the way for a deeper understanding of RORA’s biological implications.

In research settings, these cell lines serve as invaluable tools for drug discovery and development, allowing scientists to screen for compounds that can modulate RORA activity or to assess potential therapeutic strategies for RORA-related diseases. Clinically, the insights gained from studies utilizing these knockout lines could inform novel interventions tailored to conditions linked with aberrant RORA function.

Compared to traditional model systems, RORA Gene Knockout Cell Lines offer distinct advantages. They are tailored specifically for RORA-related research, minimizing background noise from unrelated genetic factors. Their robustness and reproducibility enhance the reliability of experimental results, positioning them as superior alternatives to more generalized cell lines.

For researchers, clinicians, and pharmaceutical developers seeking to explore the depths of RORA’s role in health and disease, these knockout cell lines are an essential addition to their experimental toolbox. Our company specializes in the development of high-quality, genetically modified cell lines, drawing on extensive expertise in genetic engineering and cellular biology to ensure that our products meet the highest standards of accuracy and effectiveness.

Please note that all services are for research use only. Not intended for any clinical use.

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