Gene: ROR2
Official Full Name: receptor tyrosine kinase like orphan receptor 2provided by HGNC
Gene Summary: The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01391 | ROR2 Knockout cell line (HeLa) | Human | ROR2 | 1:3~1:6 | Negative | Online Inquiry |
KO11682 | ROR2 Knockout cell line (HCT 116) | Human | ROR2 | 1:2~1:4 | Negative | Online Inquiry |
KO11683 | ROR2 Knockout cell line (HEK293) | Human | ROR2 | 1:3~1:6 | Negative | Online Inquiry |
ROR2 Gene Knockout Cell Lines represent a cutting-edge research tool that allows scientists to explore the functional role of the ROR2 gene within cellular contexts. ROR2, or Receptor Tyrosine Kinase-like Orphan Receptor 2, is implicated in several biological processes, including limb development and signaling pathways that affect cellular proliferation and differentiation. By utilizing gene-editing technologies, specifically CRISPR/Cas9, these cell lines have been engineered to lack functional ROR2, providing a platform to investigate the gene's role in various physiological and pathological conditions.
The key function of ROR2 Gene Knockout Cell Lines lies in their ability to elucidate the cellular signaling pathways activated by ROR2. By studying these knockout models, researchers can investigate the downstream effects of ROR2 deficiency, such as alterations in cell migration, morphology, and interaction with extracellular matrices. This is particularly relevant in the context of studies related to congenital disorders, cancer biology, and regenerative medicine, where ROR2 is noted to contribute to tumor progression and metastasis.
Scientific importance stems from the necessity for precise models that can mimic the complexities of human biology. These knockout cell lines have the potential for wide application in drug discovery, biomarker identification, and understanding genetic contributions to diseases. They allow researchers to test therapeutic interventions, providing essential insights into the efficacy and safety of proposed treatments.
Compared to conventional methods, ROR2 Gene Knockout Cell Lines offer a more efficient and robust framework for functional analysis. Unlike other gene manipulation techniques that may produce incomplete knockdowns or off-target effects, our proprietary lines ensure a true functional knockout, thereby enhancing experimental accuracy.
Researchers, clinicians, and pharmaceutical companies will find great value in using ROR2 Gene Knockout Cell Lines, as they facilitate a more profound understanding of disease mechanisms and therapeutic targets. Our commitment to quality and innovation is underscored by our extensive expertise in genetic engineering and cell line development, positioning us as a trusted partner in advancing biomedical research. By choosing our ROR2 Gene Knockout Cell Lines, you are investing in a product that not only meets but exceeds the standards necessary for high-impact scientific exploration.
Please note that all services are for research use only. Not intended for any clinical use.
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