Gene: RNH1
Official Full Name: ribonuclease/angiogenin inhibitor 1provided by HGNC
Gene Summary: Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35604 | RNH1 Knockout cell line (HeLa) | Human | RNH1 | 1:3~1:6 | Negative | Online Inquiry |
KO35605 | RNH1 Knockout cell line (HCT 116) | Human | RNH1 | 1:2~1:4 | Negative | Online Inquiry |
KO35606 | RNH1 Knockout cell line (HEK293) | Human | RNH1 | 1:3~1:6 | Negative | Online Inquiry |
KO35607 | RNH1 Knockout cell line (A549) | Human | RNH1 | 1:3~1:4 | Negative | Online Inquiry |
RNH1 Gene Knockout Cell Lines are genetically modified cell lines characterized by the deletion of the RNH1 gene, which encodes for the enzyme ribonuclease inhibitor. This enzyme plays a crucial role in regulating the activity of ribonucleases, enzymes responsible for the degradation of RNA, ultimately influencing RNA stability and cellular responses. By knocking out the RNH1 gene, researchers can investigate the downstream effects on RNA metabolism, cellular stress responses, and pathways implicated in diseases such as cancer and neurodegenerative disorders.
The primary function of RNH1 Gene Knockout Cell Lines lies in their ability to create a simplified model for studying RNA regulation and turnover. By understanding the disruptions caused by RNH1 deletion, scientists can assess the implications of altered ribonuclease activity on cellular functions, gene expression profiles, and overall cellular health. This insight can facilitate the identification of potential therapeutic targets for diseases associated with RNA mismanagement.
The scientific importance of these cell lines extends beyond basic research; they have practical applications in drug discovery and the development of novel therapeutic strategies. By employing RNH1 knockouts, researchers can evaluate how various compounds interact with ribonuclease pathways, leading to enhanced insights into treatments for conditions reliant on RNA metabolism.
What sets RNH1 Gene Knockout Cell Lines apart from alternative models is their specificity and precision in gene targeting, ensuring high reproducibility and reliability in experimental outcomes. Additionally, their ready availability allows for accelerated research timelines, maximizing productivity in both academic and industrial laboratories.
For researchers and clinicians, these cell lines represent a powerful tool to unlock the complexities of RNA biology, potentially leading to transformative advances in understanding health and disease mechanisms. Our company, a leader in biotechnological advancements, specializes in providing high-quality genetic tools that empower scientists to push the boundaries of their research, facilitating groundbreaking discoveries in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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