Gene: RNF25
Official Full Name: ring finger protein 25provided by HGNC
Gene Summary: The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05202 | RNF25 Knockout cell line (HeLa) | Human | RNF25 | 1:3~1:6 | Negative | Online Inquiry |
KO05203 | RNF25 Knockout cell line (HCT 116) | Human | RNF25 | 1:2~1:4 | Negative | Online Inquiry |
KO05204 | RNF25 Knockout cell line (HEK293) | Human | RNF25 | 1:3~1:6 | Negative | Online Inquiry |
KO05205 | RNF25 Knockout cell line (A549) | Human | RNF25 | 1:3~1:4 | Negative | Online Inquiry |
RNF25 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the expression of the RNF25 gene, a key player in regulating various cellular processes, including cell proliferation, apoptosis, and the response to DNA damage. These knockout models are valuable tools in molecular biology and genetics, allowing researchers to elucidate the functions of the RNF25 protein and its implications in oncogenesis and other diseases.
The primary function of RNF25 involves its role as an E3 ubiquitin ligase, which modifies target proteins through ubiquitination, thereby tagging them for degradation or altering their activity. The produced knockout cell lines enable the study of the RNF25-dependent signaling pathways and their contributions to cellular homeostasis and tumor progression. By investigating the phenotypic consequences of RNF25 loss, researchers can gain crucial insights into the molecular mechanisms underpinning various pathological conditions.
Scientifically, these cell lines have significant applications in both research and clinical settings. They are instrumental in identifying potential therapeutic targets for cancers where RNF25 is dysregulated. Furthermore, they can serve as a model for drug screening, providing a platform for determining the efficacy of novel therapeutic agents aimed at modulating the ubiquitin-proteasome system.
One of the key advantages of RNF25 Gene Knockout Cell Lines is their customized nature, which ensures consistent and reproducible results. Compared to alternative approaches such as RNA interference, these knockout lines provide a more stable and permanent solution for studying gene function, eliminating the variability associated with transient expression systems. This stability is particularly beneficial for long-term experiments and when conducting high-throughput screening.
Ultimately, the availability of RNF25 Gene Knockout Cell Lines is invaluable for researchers and clinicians aiming to deepen their understanding of molecular mechanisms and develop innovative therapeutic approaches. Our company, with its extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products that empower scientific discovery and advance therapeutic research.
Please note that all services are for research use only. Not intended for any clinical use.
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