Gene: RNF170
Official Full Name: ring finger protein 170provided by HGNC
Gene Summary: This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04125 | RNF170 Knockout cell line (HeLa) | Human | RNF170 | 1:3~1:6 | Negative | Online Inquiry |
KO04126 | RNF170 Knockout cell line (HCT 116) | Human | RNF170 | 1:2~1:4 | Negative | Online Inquiry |
KO04127 | RNF170 Knockout cell line (HEK293) | Human | RNF170 | 1:3~1:6 | Negative | Online Inquiry |
KO04128 | RNF170 Knockout cell line (A549) | Human | RNF170 | 1:3~1:4 | Negative | Online Inquiry |
RNF170 Gene Knockout Cell Lines represent a state-of-the-art biological product derived from a meticulous genetic engineering process aimed at creating a cellular model that lacks the RNF170 gene. This gene encodes for a protein involved in regulating various cellular pathways, including cell cycle progression and DNA damage response. By utilizing CRISPR/Cas9 technology, these knockout cell lines allow researchers to investigate the functional consequences of RNF170 loss, offering pivotal insights into its role in cellular processes and disease mechanisms.
The key functions of RNF170 Gene Knockout Cell Lines lie in their ability to serve as a robust platform for studying gene function and the pathophysiology of conditions linked to RNF170 dysregulation, such as certain cancers and neurodegenerative disorders. The knockout mechanism effectively eliminates the expression of the RNF170 protein, enabling the assessment of downstream effects on signaling pathways and cellular behaviors that are crucial for understanding the gene's contribution to stability and homeostasis.
The scientific importance of these cell lines extends into both research and clinical settings. Researchers can utilize these models for drug discovery, biomarker development, and therapeutic target validation, making RNF170 Gene Knockout Cell Lines suitable for basic research and potential translational applications. Their role in elucidating gene-environment interactions and disease etiology highlights their significance in advancing personalized medicine.
Compared to traditional knockdown approaches, the knockout methodology employed for these cell lines ensures complete ablation of RNF170 expression, thus providing a more accurate representation of its biological impact. This comprehensive removal eliminates any residual gene activity that could confound experimental results, offering a level of specificity and reproducibility that is unmatched by alternative models.
These innovative cell lines not only empower researchers to explore the molecular underpinnings of diseases but also provide clinicians with tools to develop more effective therapeutic strategies. By investing in RNF170 Gene Knockout Cell Lines, laboratories can leverage cutting-edge technology to accelerate their research and enhance the understanding of vital biological processes.
With extensive expertise in genetic manipulation and a commitment to advancing research, our company is dedicated to delivering high-quality biological products that meet the dynamic needs of scientists and clinicians alike. Our RNF170 Gene Knockout Cell Lines are a testament to our mission of supporting groundbreaking discoveries in genetic studies and disease research.
Please note that all services are for research use only. Not intended for any clinical use.
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