Gene: RNF149
Official Full Name: ring finger protein 149provided by HGNC
Gene Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01018 | RNF149 Knockout cell line (HEK293) | Human | RNF149 | 1:3~1:6 | Negative | Online Inquiry |
KO14466 | RNF149 Knockout cell line (HeLa) | Human | RNF149 | 1:3~1:6 | Negative | Online Inquiry |
KO14467 | RNF149 Knockout cell line (HCT 116) | Human | RNF149 | 1:2~1:4 | Negative | Online Inquiry |
KO14468 | RNF149 Knockout cell line (A549) | Human | RNF149 | 1:3~1:4 | Negative | Online Inquiry |
RNF149 Gene Knockout Cell Lines are innovative biological tools designed to enable researchers to investigate the functional roles of the RNF149 gene, which encodes an E3 ubiquitin ligase implicated in cellular processes such as protein degradation and signaling pathways. By employing the CRISPR/Cas9 gene-editing technology, these knockout cell lines allow for the precise deletion of the RNF149 gene, facilitating in-depth studies of its contributions to various biological processes and disease states.
The primary mechanism behind the utility of RNF149 Gene Knockout Cell Lines lies in their ability to create a defined genetic background in which the effects of RNF149 depletion can be systematically studied. This offers unparalleled insight into the gene’s involvement in mechanisms such as cell cycle regulation, apoptosis, and immune response modulation, enabling researchers to elucidate its role in cancer biology, neurodegenerative disorders, and beyond.
The scientific significance of these cell lines is profound, as they provide a standardized model for experimentation that can accelerate discoveries in both academia and the biopharmaceutical industry. Researchers can utilize these knockout models to identify novel drug targets, validate therapeutic pathways, and test the efficacy of new compounds in a controlled environment, enhancing the translational potential of their findings.
What sets RNF149 Gene Knockout Cell Lines apart from alternative products is their rigorous validation and optimization for reproducibility and consistency across assays. Each cell line is thoroughly characterized to ensure the absence of RNF149 expression, and its performance is validated in various experimental contexts, providing confidence in the reliability of the results generated.
For researchers and clinicians focused on elucidating the complexities of gene function and its implications for disease, these knockout cell lines represent a valuable resource. By enabling targeted investigations into the RNF149 gene, scientists can advance their understanding of critical biological pathways and contribute to the development of innovative therapeutic strategies.
At [Your Company Name], our expertise in gene editing technologies and commitment to providing high-quality research tools position us as a leading supplier of cutting-edge biological products. We are dedicated to supporting scientific innovation and discovery, empowering researchers to push the boundaries of knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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