Gene: RNF146
Official Full Name: ring finger protein 146provided by HGNC
Gene Summary: Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25609 | RNF146 Knockout cell line (HeLa) | Human | RNF146 | 1:3~1:6 | Negative | Online Inquiry |
KO25610 | RNF146 Knockout cell line (HCT 116) | Human | RNF146 | 1:2~1:4 | Negative | Online Inquiry |
KO25611 | RNF146 Knockout cell line (HEK293) | Human | RNF146 | 1:3~1:6 | Negative | Online Inquiry |
KO25612 | RNF146 Knockout cell line (A549) | Human | RNF146 | 1:3~1:4 | Negative | Online Inquiry |
RNF146 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the RNF146 gene, a crucial component involved in the regulation of multiple cellular pathways, including those associated with ubiquitination and protein degradation. The knockout of this gene allows researchers to investigate the functional roles of RNF146 in various biological processes, offering valuable insights into cellular behavior and molecular mechanisms.
The key mechanism of action for RNF146 knockout involves the disruption of normal ubiquitin-mediated protein turnover, which affects various signaling cascades and cellular responses in the absence of the RNF146 protein. By utilizing these specialized cell lines, scientists can elucidate RNF146's role in key cellular events such as apoptosis, cell proliferation, and the response to stress, leading to a deeper understanding of its effects in normal physiology and disease states.
The scientific importance of RNF146 Gene Knockout Cell Lines is particularly pronounced in the fields of cancer research, neurobiology, and developmental biology. Their application in research can lead to breakthroughs in understanding diseases driven by dysregulated protein homeostasis and aberrant cell signaling. Clinically, these insights can inform potential therapeutic strategies, highlighting the relevance of RNF146 in the development of targeted treatments.
One of the specific advantages of RNF146 knockout cell lines is their ability to provide a controlled experimental environment to study gene function without the confounding effects present in in vivo models. Compared to other knockout systems, our cell lines offer validated, reproducible models that ensure consistent results across experiments, which enhances the reliability of scientific findings.
This product is invaluable for researchers and clinicians aiming to explore the complexities of genetic and cellular networks. The ability to model the effects of RNF146 deficiency allows for enhanced experimental design, paving the way for innovative approaches to tackle pressing biological questions and therapeutic challenges.
Our company prides itself on its commitment to providing high-quality, well-characterized cellular models backed by extensive research expertise. By offering RNF146 Gene Knockout Cell Lines, we empower the scientific community with tools designed to facilitate groundbreaking research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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