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RNF103 Knockout Cell Lines

Gene: RNF103

Official Full Name: ring finger protein 103provided by HGNC

Gene Summary: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34430 RNF103 Knockout cell line (HeLa) Human RNF103 1:3~1:6 Negative Online Inquiry
KO34431 RNF103 Knockout cell line (HCT 116) Human RNF103 1:2~1:4 Negative Online Inquiry
KO34432 RNF103 Knockout cell line (HEK293) Human RNF103 1:3~1:6 Negative Online Inquiry
KO34433 RNF103 Knockout cell line (A549) Human RNF103 1:3~1:4 Negative Online Inquiry

Background

RNF103 Gene Knockout Cell Lines are specialized laboratory tools designed for the study of the RNF103 gene, which encodes an E3 ubiquitin ligase implicated in regulating various cellular processes, including protein degradation, signal transduction, and cellular response to stress. Developed through advanced CRISPR-Cas9 gene-editing techniques, these cell lines present a novel approach for researchers aiming to investigate the functional roles of RNF103 in both normal physiology and disease states, particularly cancer and neurodegenerative disorders.

The key function of the RNF103 Gene Knockout Cell Lines lies in their ability to provide a controlled environment where the effects of RNF103 gene loss can be analyzed. By completely disrupting the expression of RNF103, researchers can elucidate pathways influenced by ubiquitin-mediated proteolysis and assess resultant phenotypic changes. This model system offers insights into how modifying RNF103 activity might alter cellular responses to therapeutic agents, with the potential to unveil novel drug targets.

In the realm of scientific research and clinical applications, these cell lines hold significant value. Their versatility enables usage in various experimental setups, including drug response assays, mechanistic studies involving proteostasis, and high-throughput screening. Furthermore, they serve as a platform for exploring the role of the RNF103 gene in diseases characterized by aberrant protein homeostasis, thereby contributing to the development of innovative treatment paradigms.

Compared to traditional cell models, RNF103 Gene Knockout Cell Lines afford researchers the specificity and precision required to discern the consequences of gene deletion with unparalleled clarity. This capability accelerates the pace of discovery, as investigators can swiftly transition from hypothesis generation to validation, ensuring efficient resource utilization.

For researchers and clinicians seeking to unravel the complexities of ubiquitin signaling pathways, RNF103 Gene Knockout Cell Lines are invaluable tools that provide an edge in scientific exploration. By leveraging these advanced cell models, professionals can enhance their understanding of gene function in health and disease.

Our company specializes in the development of cutting-edge biological products tailored for research applications. With a commitment to scientific excellence and innovation, we ensure that our offerings, including RNF103 Gene Knockout Cell Lines, empower researchers to push the boundaries of discovery and advance their work in molecular biology and genetics.

Please note that all services are for research use only. Not intended for any clinical use.

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